Protection by Chrysanthemum zawadskii extract from liver damage of mice caused by carbon tetrachloride is maybe mediated by modulation of QR activity

Seo, Ji Yeon; Lim, Soon Sung; Park, Jia; Lim, Ji Sun; Kim, Hyo Jung; Kang, Hui Jung; Park, Jung Han Yoon; Kim, Jong Sang

doi:10.4162/nrp.2010.4.2.93

Cited by 22 publications

(14 citation statements)

References 22 publications

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“…The effective constituents comprised terpenoids and essential oils, as well as flavonoids and polysaccharides. Terpenoids and flavonoids are considered the active pharmaceutical ingredients (2), and flower extracts have been shown to have numerous pharmacological properties, including anti-allergic, anti-inflammatory and anticancer activities (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix

Zheng

et al. 2014

International Journal of Molecular Medicine

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Chrysanthemum zawadskii has been proven to possess hair growth activity and has been used as treatment for hair loss. The aim of this study was to provide a novel explanation of the mechanism by which Chrysanthemum zawadskii extracts (CZe) promote hair growth and to characterize the affected hair follicle (HF) regions and the progression of growth. The n-butanol and water fractions of CZe were used for hair growth induction by topical application to the backs of C57BL/6 mice for up to 30 days. To investigate cell development during HF morphogenesis, bromodeoxyuridine-labeled skin sections were detected using immunohistochemistry. The results showed that the water fraction of CZe promoted hair shaft production and induced premature entry of telogen HFs into the anagen. Subsequently, immunohistochemical studies indicated that the water fraction of CZe stimulated the differentiation and proliferation of pluripotent epidermal matrix cells in the matrix region and epithelial stem cells in the basal layer of the epidermis. Additionally, flavonoids were identified as effective constituents. Therefore, the findings of this study suggested that the water fraction of CZe may be developed as a therapeutic agent for the prevention of hair loss.

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Section: Introductionmentioning

confidence: 99%

Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix

Zheng

et al. 2014

International Journal of Molecular Medicine

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“…C. zawadskii Herbich var. latilobum Kitamura extract (CZE) has been shown to harbor many pharmacological properties, including anticancer, antiallergic, anti-inflammatory, and antioxidative stress activities, along with protective effects against liver damage [17–22]. …”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect ofChrysanthemum zawadskiiHerbich var.latilobumKitamura Extract on RANKL-Induced Osteoclast Differentiation

Hwang

Erkhembaatar

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Chrysanthemum zawadskii Herbich var. latilobum Kitamura, known as “Gujulcho” in Korea, has been used in traditional medicine to treat various inflammatory diseases, including rheumatoid arthritis. However, these effects have not been tested on osteoclasts, the bone resorbing cells that regulate bone metabolism. Here, we investigated the effects of C. zawadskii Herbich var. latilobum Kitamura ethanol extract (CZE) on osteoclast differentiation induced by treatment with the receptor activator of NF-κB ligand (RANKL). CZE inhibited osteoclast differentiation and formation in a dose-dependent manner. The inhibitory effect of CZE on osteoclastogenesis was due to the suppression of ERK activation and the ablation of RANKL-stimulated Ca2+-oscillation via the inactivation of PLCγ2, followed by the inhibition of CREB activation. These inhibitory effects of CZE resulted in a significant repression of c-Fos expression and a subsequent reduction of NFATc1, a key transcription factor for osteoclast differentiation, fusion, and activation in vitro and in vivo. These results indicate that CZE negatively regulates osteoclast differentiation and may be a therapeutic candidate for the treatment of various bone diseases, such as postmenopausal osteoporosis, rheumatoid arthritis, and periodontitis.

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“…Chrysanthemum zawadskii is one of the species of the genus Chrysanthemum and has traditionally been used in folk medicine, known as 'Gujeolcho' in Korea for the treatment of various diseases. Chrysanthemum zawadskii extracts (CZE) has been shown to have anti-inflammatory and anti-oxidative stress activities in RAW 264.7 murine macrophage cells (7) and one of the fractions derived from CZE exerts protective effects against carbon tetrachloride (CCl 4 )-induced hepatotoxicity in mice via the induction of detoxifying enzyme, NAD(P)H: (quinone acceptor) oxidoreductase 1 (8).…”

Section: Introductionmentioning

confidence: 99%

Chrysanthemum zawadskii extract protects osteoblastic cells from highly reducing sugar-induced oxidative damage

Suh

Rhee

Jung

et al. 2013

International Journal of Molecular Medicine

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In this study, Chrysanthemum zawadskii extract (CZE) was investigated to determine its effects on 2-deoxy-D-ribose (dRib)-induced oxidative damage and cellular dysfunction in the MC3T3-E1 mouse osteoblastic cell line. Osteoblastic cells were treated with the highly reducing sugar, dRib, in the presence or absence of CZE. Cell viability, apoptosis and reactive oxygen species (ROS) production were subsequently examined. It was observed that dRib reduced cell survival, while it markedly increased the intracellular levels of ROS and apoptosis. However, pre-treatment of the cells with CZE attenuated all the dRib-induced effects. The antioxidant, N-acetyl-L-cysteine (NAC), also prevented dRib-induced oxidative cell damage. In addition, treatment with CZE resulted in a significant increase in alkaline phosphatase (ALP) activity and collagen content, as well as in the expression of genes associated with osteoblast differentiation [ALP, collagen, osteopontin (OPN), osteoprotegerin (OPG), bone sialoprotein (BSP), osteocalcin (OC) and bone morphogenetic protein (BMP)2, BMP4 and BMP7]. In mechanistic studies of the antioxidative potential of CZE, we found that CZE reversed the dRib-induced decrease in the expression of phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT)1 and AKT2 genes, which are master regulators of survival-related signaling pathways. CZE also upregulated the gene expression of the antioxidant enzymes, superoxide dismutase (SOD)2, SOD3 and glutathione peroxidase 4 (GPx4), which was inhibited by dRib. Taken together, these results suggest that CZE attenuates dRib-induced cell damage in osteoblastic cells and may be useful for the treatment of diabetes-associated bone disease.

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Protection by Chrysanthemum zawadskii extract from liver damage of mice caused by carbon tetrachloride is maybe mediated by modulation of QR activity

Cited by 22 publications

References 22 publications

Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix

Chrysanthemum zawadskii extract induces hair growth by stimulating the proliferation and differentiation of hair matrix

Inhibitory Effect ofChrysanthemum zawadskiiHerbich var.latilobumKitamura Extract on RANKL-Induced Osteoclast Differentiation

Chrysanthemum zawadskii extract protects osteoblastic cells from highly reducing sugar-induced oxidative damage

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