Protection against the New Equine Influenza Virus Florida Clade I Outbreak Strain Provided by a Whole Inactivated Virus Vaccine

Abstract

Equine influenza virus (EIV) is a major cause of respiratory disease in horses. Vaccination is an effective tool for infection control. Although various EIV vaccines are widely available, major outbreaks occurred in Europe in 2018 involving a new EIV H3N8 FC1 strain. In France, it was reported that both unvaccinated and vaccinated horses were affected despite >80% vaccination coverage and most horses being vaccinated with a vaccine expressing FC1 antigen. This study assessed whether vaccine type, next to antigenic difference between vaccine and field strain, plays a role. Horses were vaccinated with an ISCOMatrix-adjuvanted, whole inactivated virus vaccine (Equilis Prequenza) and experimentally infected with the new FC1 outbreak strain. Serology (HI), clinical signs, and virus shedding were evaluated in vaccinated compared to unvaccinated horses. Results showed a significant reduction in clinical signs and a lack of virus shedding in vaccinated horses compared to unvaccinated controls. From these results, it can be concluded that Equilis Prequenza provides a high level of protection to challenge with the new FC1 outbreak strain. This suggests that, apart from antigenic differences between vaccine and field strain, other aspects of the vaccine may also play an important role in determining field efficacy.

Analisis Risiko Kualitatif terhadap MasuknyaVirus Equine Influenza ke Indonesia MelaluiPemasukan Kuda Asal Belanda

“…Pemasukan kuda dari Belanda yang dilakukan selama ini memiliki risiko membawa virus EI ke Indonesia karena Belanda memiliki status dicurigai (suspected disease) terinfeksi virus EI pada kuda yang peliharaan sejak tahun 2009 hingga 2020 (WOAH, 2022). Reemers et al (2020) telah mengidentifikasi wabah di Belanda pada tahun 2018 di Kota Venlo, sebagaimana yang juga dilaporkan oleh WOAH (2019b). Oleh karena itu, analisis risiko diperlukan untuk menilai besaran risiko pemasukan virus EI dan diharapkan dapat menunjang tindakan pencegahan masuknya virus tersebut ke Indonesia.…”