Protection against radiation oxidative damage in mice by Triphala

Sandhya, Tera; Lathika, K. M.; Pandey, Badri N.; Bhilwade, Hari N.; Chaubey, R.C.; Priyadarsini, K. Indira; Mishra, Kaushala Prasad

doi:10.1016/j.mrgentox.2006.05.006

Cited by 51 publications

(44 citation statements)

References 23 publications

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“…Triphala recipe possesses many biological activities including antimutagenic (Kaur et al, 2002), radioprotective (Sandhya et al, 2006a), hypocholesterolaemic (Saravanan et al, 2007), immunomodulatory (Srikumar et al, 2005), anticancer (Deep et Sandhya et al, 2006b), and anti-oxidant activities (Naik et al, 2005). Moreover, this recipe has an anti-inflammatory activity on adjuvant-induced arthritis in mice (Rasool and Sabina, 2007).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of anti-inflammatory and antinociceptive activity of Triphala recipe

Sireeratawong¹,

Jaijoy²,

Soonthornchareonnon³

2013

Afr. J. Trad. Compl. Alt. Med.

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The anti-inflammatory and antinociceptive activities of Triphala recipe were studied in animal models. Triphala recipe (4 mg/ear) significantly exhibited an inhibitory effect on the ear edema formation induced by ethyl phenylpropiolateinduced, but not on the arachidonic acid -induced ear edema in rats. Furthermore, Triphala recipe at the doses of 300, 600 and 1,200 mg/kg significantly reduced carrageenan-induced hind paw edema. Next, the anti-inflammatory action in chronic inflammation was measured using the cotton pellet-induced granuloma formation assay in rats. Triphala recipe (1,200 mg/kg) reduced neither transudative weight nor granuloma formation. It also did not affect on body weight gain and thymus weight indicating that Triphala recipe does not have a steroid-like effect. In antinociceptive study, Triphala recipe (300, 600, 1,200 mg/kg), elicited significant inhibitory effect on both phases, especially in late phase, of the formalin test in mice suggesting that the antinociceptive action of Triphala recipe may be via both peripheral and at least partly centrally acting.

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Section: Introductionmentioning

confidence: 99%

Evaluation of anti-inflammatory and antinociceptive activity of Triphala recipe

Sireeratawong¹,

Jaijoy²,

Soonthornchareonnon³

2013

Afr. J. Trad. Compl. Alt. Med.

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“…Triphala, a well-known Ayurvedic herbal formulation effectively regulates the functions of digestive system and enhances the strength of immune system, lungs, urinary tract and the muscles. Triphala is scientifically proven for various activities such as anti-mutagenic activity (Kaur et al, 2002), cytochrome P450 inhibitory activity (Ponnusankar et al, 2011) and protective activity against radiation oxidative damage (Sandhya et al, 2006). All three plants used in Triphala powder are given in Fig.…”

Section: Yoga and Other Exercisesmentioning

confidence: 99%

Adverse Health Effects of Tobacco and Role of Ayurveda in their Reduction

Semwal¹,

Mishra²,

Chauhan³

et al. 2015

J. of Medical Sciences

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Tobacco in all forms is dangerous for human health and caused various diseases such as heart attacks, hypertension, strokes, pulmonary disease and cancer. Smoking is a leading cause of lung cancer whereas mouth cancer is mainly caused by chewing of tobacco. Similar to the first hand smoking, passive smoking also affects a healthy human. Various researches confirmed the presence of about 600 ingredients in cigarettes which produced about 69 carcinogenic compounds after burning. Ayurveda is however helpful in the reduction of side-effects of tobacco by various ways including the use of Rasayana such as Ashwagandha, Shatavari, Bala and Ginseng. Moreover, Yoga can help in releasing tension and stress and increase the strength and vitality without using any form of tobacco. Herein, an evidence-based report is prepared from various earlier important studies to aware public for the dangerous health effects of tobacco. This report mainly highlights major facts of the use of tobacco, its adverse effects globally and role of Ayurveda in their reduction.

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“…[19][20][21] Exposure to ionizing radiation alters the balance and leads to the irreversible changes in the tridoshas that are visible as radiation sickness and when severe causes mortality. 15 The classical Ayurvedic drugs Amritaprasham, [5][6][7] Ashwaganda rasayana, [5][6][7] Brahma Rasayana, [6][7][8][9][10][11][12][13][14] Chyavanaprasha, 14 Narasimha Rasayana, [5][6][7] and Triphala, [15][16][17][18] which belong to Rasayana group of drugs in Ayurveda (drug that imparts rejuvenating effects to the cell and tissues) are reported to possess radioprotective effects and are addressed in this review.…”

Section: Traditional Ayurvedic Drugs With Radioprotective Effectsmentioning

confidence: 99%

“…15 Triphala is observed to exert radioprotective effects when administered through both intraperitoneal 15,16 and oral routes. 17 Jagetia et al 15 have observed that administration of aqueous extract of Triphala (5-20 mg/kg) by the intraperitoneal route for 5 consecutive days prior to supralethal dose of 10 Gy γ-radiation protected mice against radiation sickness and mortality. 15 The best protection was observed for 10 mg/kg Triphala as nearly 60% survival was observed at the end of the study period of 30 days postirradiation.…”

Section: Triphalamentioning

confidence: 99%

“…The sulfydryl compounds were found to be good radioprotectors but unfortunately their inherent toxic effects at their optimal protective doses were a major deterrent to their clinical use. 3,4 Herbal drugs offer an alternative to synthetic compounds and are considered either nontoxic or less toxic 3 and experimental studies have shown that the Ayurvedic drugs Amritaprasham, [5][6][7] Ashwaganda Rasayana, [5][6][7] Brahma Rasayana, [6][7][8][9][10][11][12][13][14] Chyavanaprasha, 14 Narasimha Rasayana, [5][6][7] and Triphala [15][16][17][18] possess radioprotective effects. In the current review, for the first time an attempt is made to summarize these observations with emphasis on the plausible reasons responsible for the radioprotective effects.…”

Section: Introductionmentioning

confidence: 99%

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Rasayana Drugs From the Ayurvedic System of Medicine as Possible Radioprotective Agents in Cancer Treatment

Baliga

Meera²,

Vaishnav

et al. 2013

Integr Cancer Ther

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The use of ionizing radiation, which is the cornerstone of cancer treatment, is compromised by the radiosensitivity of normal tissues. A chemical that can give selective benefit to the normal cells against the deleterious effects of ionizing radiation has been a long-sought goal. However, most of the compounds studied have shown inadequate clinical application owing to their inherent toxicity, undesirable side effects, and high cost. Studies carried out in the past 2 decades have shown that some of the classical Indian Ayurvedic drugs (Amritaprasham, Ashwagandha Rasayana, Brahma Rasayana, Chyavanprasha, Narasimha Rasayana, and Triphala Churna) possess radioprotective effects. In the current review, an attempt is made to summarize the radioprotective observations of these Ayurvedic drugs and the mechanisms responsible for the radioprotective effects.

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Protection against radiation oxidative damage in mice by Triphala

Cited by 51 publications

References 23 publications

Evaluation of anti-inflammatory and antinociceptive activity of Triphala recipe

Evaluation of anti-inflammatory and antinociceptive activity of Triphala recipe

Adverse Health Effects of Tobacco and Role of Ayurveda in their Reduction

Rasayana Drugs From the Ayurvedic System of Medicine as Possible Radioprotective Agents in Cancer Treatment

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