Protection against Oxidative Stress-induced Hepatic Injury by Intracellular Type II Platelet-activating Factor Acetylhydrolase by Metabolism of Oxidized Phospholipids in Vivo

Kono, Nozomu; Inoué, Takao; Yoshida, Yasukazu; Sato, Hiroyuki; Matsusue, Tomokazu; Itabe, Hiroyuki; Niki, Etsuo; Aoki, Junken; Arai, Hiroyuki

doi:10.1074/jbc.m708622200

Cited by 72 publications

(79 citation statements)

References 73 publications

(38 reference statements)

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“…The plasma form is secreted by cells of hematopoietic origin and is associated with circulating lipoproteins (Lp-PLA 2 ). The intracellular cytosolic form is expressed mainly in hepatocytes and epithelial cells of kidney and intestine ( 42 ). These phospholipases display high activity with sn -2 oxidized chains of phospholipids.…”

Section: Discussionmentioning

confidence: 99%

Reductive metabolism increases the proinflammatory activity of aldehyde phospholipids

Vladykovskaya¹,

Ozhegov²,

Hoetker

et al. 2011

Journal of Lipid Research

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Section: Discussionmentioning

confidence: 99%

Reductive metabolism increases the proinflammatory activity of aldehyde phospholipids

Vladykovskaya¹,

Ozhegov²,

Hoetker

et al. 2011

Journal of Lipid Research

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“…This suggests that hydrolysis of oxidized phospholipids is a primordial function of PAF-AH. Correspondingly, ablation of the type II PAF-AH sensitizes mice to the toxic effects associated with CCl 4 -induced oxidant stress in the liver (8), showing that this protective role is retained by the mammalian enzyme. These combined observations point to an essential role of PAF-AHs as scavengers of apoptotic, short-chained phospholipids.…”

Section: Apoptosismentioning

confidence: 99%

“…For example, the plasma isoform is expressed by macrophages, which retain a portion of the activity, while the type II liver isoform is found in several soft tissues (7), particularly those rich in epithelial cells (8). Comprehensive analyses of the distribution of PAF-AHs have not been conducted, but this can be anticipated by the distribution of their mRNAs.…”

Section: Location Location Locationmentioning

confidence: 99%

The emerging roles of PAF acetylhydrolase

McIntyre

Prescott

Stafforini

2009

Journal of Lipid Research

154

119

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Platelet-activating factor (PAF), a phospholipid autacoid with potent effects throughout the innate immune system, is selectively degraded by two small families of PAF acetylhydrolases (PAF-AHs). These Ca 21 -independent phospholipases A 2 display remarkable specificity for the length of the sn -2 residue, but this selectivity is lost as the residue gains oxygen functions. Two of the PAF-AHs therefore are specific oxidized phospholipid phospholipases that reduce inflammation, but also remove oxidatively truncated phospholipids that induce apoptosis. The roles of these enzymes are manifold, and their separate and combined functions are now being addressed in model systems and clinical studies-McIntyre, T. M., S. M. Prescott, and D. M. Stafforini. The emerging roles of PAF acetylhydrolase.

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“…Stafforini et al ( 25 ) showed that the secreted form of Lp-PLA 2 released F 2 -isoprostanes, the end products of lipid oxidation, from the sn-2 position of phosphatidylcholines with high affi nity. Kono et al ( 26 ) have reported that intracellular type II Lp-PLA 2 , which shares homology with the plasma enzyme Lp-PLA 2 , is involved in the metabolism of esterifi ed 8-iso-PGF 2 ␣ . Similar to previous fi ndings ( 3,27 ), this study also showed a positive correlation between changes in circulating Lp-PLA 2 activity and urinary 8-epi-PGF 2 ␣ concentrations.…”

Section: Downloaded Frommentioning

confidence: 99%

Replacing with whole grains and legumes reduces Lp-PLA2 activities in plasma and PBMCs in patients with prediabetes or T2D

Kim

Jeung

Jeong

et al. 2014

Journal of Lipid Research

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This article is available online at http://www.jlr.org Supplementary key words lipoprotein-associated phospholipase A 2 • peripheral blood mononuclear cell • type 2 diabetes Lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) has been consistently higher among type 2 diabetics than nondiabetics ( 1-3 ), and independently predicts incident T2D ( 4 ). However, little is known about the dietary treatment that may alter circulating Lp-PLA 2 activity levels. In a recent large cross-sectional study of men and women, the observation of an inverse association between protein intakes and circulating Lp-PLA 2 activity suggests that nutritional factors may have the potential to infl uence Lp-PLA 2 activity ( 5 ). Additionally, a small interventional study with low-calorie diet showed that an average 10 kg weight loss achieved over 4 months in healthy obese women was associated with a 10% decrease in Lp-PLA 2 activity ( 6 ). These recent studies ( 5, 6 ) suggest that diet may represent a potentially modifi able pathway through which Lp-PLA 2 activity can be altered. However, no study has examined the effects of dietary treatment on circulating Lp-PLA 2 activity in patients with T2D.According to the 2010 Korean National Health and Nutrition Survey (KNHANES V-1), carbohydrate-derived calories account for 65% of total caloric intake, and cooked refi ned rice is the major source of carbohydrates in middle-aged adults. Because of this high carbohydrate intake, Abstract To determine dietary effects on circulating lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) activity and enzyme activity in peripheral blood mononuclear cells (PBMCs), 99 patients with impaired fasting glucose, impaired glucose tolerance, or newly-diagnosed T2D were randomly assigned to either a control group (usual diet with refi ned rice) or the whole grain and legume group. Substitution of whole grains and legumes for refined rice was associated with the replacement of 7% of energy from carbohydrates with energy from protein (about 4%) and fat. After 12 weeks, the whole grain and legume group showed a signifi cant decrease in fasting glucose, insulin, homeostasis model assessment-insulin resistance, hemoglobin A 1c , malondialdehyde, plasma Lp-PLA 2 activity, and oxidized LDL (ox-LDL), and an increase in LDL particle size. The changes ( ⌬ s) in these variables in the whole grain and legume group were signifi cantly different from those in controls after adjustment for the baseline levels. When all subjects were considered, ⌬ plasma Lp-PLA 2 positively correlated with ⌬ glucose, ⌬ PBMC Lp-PLA 2 , ⌬ ox-LDL, and ⌬ urinary 8-epiprostaglandin F 2 ␣ after being adjusted for confounding factors. The ⌬ PBMC Lp-PLA 2 correlated positively with ⌬ glucose and ⌬ ox-LDL, and negatively with ⌬ LDL particle size and baseline PBMC Lp-PLA 2 . The substitution of whole grains and legumes for refi ned rice resulted in a reduction in Lp-PLA 2 activities in plasma and PBMCs partly through improved glycemic control, increased consumption of protein relative to carbohydrate, an...

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Protection against Oxidative Stress-induced Hepatic Injury by Intracellular Type II Platelet-activating Factor Acetylhydrolase by Metabolism of Oxidized Phospholipids in Vivo

Cited by 72 publications

References 73 publications

Reductive metabolism increases the proinflammatory activity of aldehyde phospholipids

Reductive metabolism increases the proinflammatory activity of aldehyde phospholipids

The emerging roles of PAF acetylhydrolase

Replacing with whole grains and legumes reduces Lp-PLA2 activities in plasma and PBMCs in patients with prediabetes or T2D

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