Protection against Iron Toxicity in Vitamin E-deficient Piglets and Mice by Vitamin E and Synthetic Antioxidants

The Influence of Diet on the Acute Toxicity of Injectable Iron Preparations in the Mouse

“…Lannek and Tollerz (1962) suggested from their experimental results that large amounts of iron were capable of destroying Vitamin E in vivo, this concept agreeing in general terms with that previously outlined by Golberg & Smith (1960). Tollerz & Lannek (1964) showed that synthetic antioxidants were capable of protecting Vitamin E-deficient mice against iron toxicity whether given prior to the iron or even simultaneously with the iron.…”

“…In our experiments the daily intake of a-and f-tocopherols from Oxoid Breeding Diet was approximately 7.5 mg/kg and thus protection can be achieved with a rather lower total dose of Vitamin E administered by injection. Subsequently Tollerz & Lannek (1964) showed that protection can be achieved not only with Vitamin E but with synthetic antitoxidants. Brownlee (1946) described a very similar situation in rats using ferrous salts.…”

Increased Myocardial and Hepatic Iron Concentration in Pigs with Microangiopathy (Mulberry Heart Disease) as a Risk Factor of Oxidative Damage

“…1971;Williams et al. 1975: Dougherty et al, 1981 whereas adequate vitamin E intake protects against iron toxicity [Tollerz and Lannek, 1964: Dougherty et al, 1981: Dil lard et ah, 1984Hershko et ah. 1987],…”

Selenium

“…Death results from an Fe-induced lipid peroxidation in tissues. Pretreatment with Se, vitamin E, or ethoxyquin was protective against toxic effects of injectable Fe (Tollerz and Lannek, 1964;Hill et al, 1999).…”

“…As an example in swine, SGOT and ornithine carbaryl transferase (OCT) are useful indicators of muscular dystrophy and liver necrosis, respectively (Wretlind et al, 1959). Enzyme tests are very sensitive, and an elevation of enzyme activity in serum is usually discovered before any pathological changes or clinical signs appear (Tollersrud, 1973).…”