Protection against influenza infection requires early recognition by inflammatory dendritic cells through C-type lectin receptor SIGN-R1

Palomino‐Segura, Miguel; Perez, Laurent; Farsakoglu, Yagmur; Virgilio, Tommaso; Latino, Irene; D’Antuono, Rocco; Chatziandreou, Nikolaos; Pizzagalli, Diego Ulisse; Wang, Guojun; Garcı́a-Sastre, Adolfo; Sallusto, Federica; Carroll, Michael; Neyrolles, Olivier; González, Santiago F.

doi:10.1038/s41564-019-0506-6

Cited by 29 publications

(36 citation statements)

References 55 publications

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“…Using the same infection model, we previously showed that inflammatory DCs (IDCs) were the major producers of CXCL9 and CXCL10 at 3 d.p.i. [2]. Moreover, earlier studies have shown a critical role of CXCR3 in the recruitment of γδ T cells in influenzainfected sites, which facilitated the elimination of pathogens [28].…”

Section: Wwweji-journaleumentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

“…The trachea plays a critical role in the host defense against influenza virus by limiting viral replication and supporting the development of the adaptive immune responses during the early phase of viral infection . The tracheal mucosa is characterized by a high frequency of innate immune cells that respond to external threats . Among them, γδ T cells are characterized by a diverse range of TCRs, with specific Vγ‐Vδ combinations, which are used as indicators of their anatomical location and function .…”

Section: Introductionmentioning

confidence: 99%

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Early production of IL‐17A by γδ T cells in the trachea promotes viral clearance during influenza infection in mice

et al. 2019

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The innate immune response generated against influenza infection is critical for the inhibition of viral dissemination. The trachea contains different types of innate immune cells that protect the respiratory tract from pathogen invasion. Among them, γδ T cells have the ability to rapidly generate large amounts of pro‐inflammatory cytokines to preserve mucosal barrier homeostasis during infection. However, little is known about their role during the early phase of influenza infection in the airways. In this study, we found that, early after infection, γδ T cells are recruited and activated in the trachea and outnumber αβ T cells during the course of the influenza infection that follows. We also showed that the majority of the recruited γδ T cells express the Vγ4 TCR chain and infiltrate in a process that involves the chemokine receptor CXCR3. In addition, we demonstrated that γδ T cells promote the recruitment of protective neutrophils and NK cells to the tracheal mucosa. Altogether, our results highlight the importance of the immune responses mediated by γδ T cells.

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Section: Wwweji-journaleumentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Early production of IL‐17A by γδ T cells in the trachea promotes viral clearance during influenza infection in mice

et al. 2019

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“…The authors proposed that N-linked glycans present on HA facilitate the interaction with DC-SIGN as an attachment factor and, thereby, enhance virus infection. Indeed, other IAV subtypes, including H1 and H3 viruses, were shown to bind and infect DC-SIGN-expressing cells in the absence of sialic acid (61,62,69). In addition to DC-SIGN, liver/lymph node-specific intercellular adhesion molecule 3-grabbing nonintegrin (L-SIGN), a protein that shares high sequence homology to DC-SIGN but is expressed on endothelial cells of liver and lymph nodes, has been demonstrated to bind IAV (61).…”

Section: Figmentioning

confidence: 99%

Breaking the Convention: Sialoglycan Variants, Coreceptors, and Alternative Receptors for Influenza A Virus Entry

Karakus

Pohl

Stertz

2020

J Virol

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The influenza A virus (IAV) envelope protein hemagglutinin binds α2,6- or α2,3-linked sialic acid as a host cell receptor. Bat IAV subtypes H17N10 and H18N11 form an exception to this rule and do not bind sialic acid but enter cells via major histocompatibility complex (MHC) class II. Here, we review current knowledge on IAV receptors with a focus on sialoglycan variants, protein coreceptors, and alternative receptors that impact IAV attachment and internalization beyond the well-described sialic acid binding.

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“…CARMA3 was involved in the RIG-I-MAVS pathway, and was shown to play a negative role in regulating host antiviral responses, but a positive role in inducing proinflammatory cytokines leading to immunopathology. 105 Other PRRs such as C-type lectin receptors, TLRs, and formyl peptide receptors are also involved in the initial inflammatory responses [107][108][109][110][111] (►Table 1).…”

Section: Tlr7mentioning

confidence: 99%

Influenza Virus in Community-Acquired Pneumonia: Current Understanding and Knowledge Gaps

Yang

et al. 2020

Semin Respir Crit Care Med

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AbstractInfluenza virus infection poses a heavy burden on global health and economics. With the advancement in viral pathogen detection methods, the role of virus infection in community-acquired pneumonia has been increasingly recognized. The disease spectrum of influenza ranges from asymptomatic infection to severe or even fatal illness. Progress has been made in recent years to identify risk factors including lymphopenia and hypoxia for influenza mortality. Immunopathology plays an important role in influenza pathogenesis. The disturbed homeostasis after virus infection consists of both an excessive inflammatory phase and an immune suppression phase, collectively described as viral sepsis. Multiple antiviral therapies have been tested and some were advanced to late-phase clinical trials, including polymerase inhibitors, hemagglutinin inhibitors, host-acting antivirals, monoclonal antibodies, and adjunctive immunomodulatory therapies. Combination therapies have been shown to increase antiviral efficacy and genetic resistance barrier. In this review, we summarized the recent advances in our understanding of the disease pathogenesis, as well as the progress in antiviral therapy development. We also pointed out current key knowledge gaps in influenza research. Hopefully, experience gained from seasonal influenza research will prepare us for the next influenza pandemic and emerging respiratory pathogens.

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Protection against influenza infection requires early recognition by inflammatory dendritic cells through C-type lectin receptor SIGN-R1

Cited by 29 publications

References 55 publications

Early production of IL‐17A by γδ T cells in the trachea promotes viral clearance during influenza infection in mice

Early production of IL‐17A by γδ T cells in the trachea promotes viral clearance during influenza infection in mice

Breaking the Convention: Sialoglycan Variants, Coreceptors, and Alternative Receptors for Influenza A Virus Entry

Influenza Virus in Community-Acquired Pneumonia: Current Understanding and Knowledge Gaps

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