Protection against aflatoxin-B1-induced liver mutagenesis by Scutellaria baicalensis

Boer, Johan G. de; Quiney, Brendan; Walter, Patrick; Thomas, C. J.; Hodgson, Kimberley; Murch, Susan J.; Saxena, Praveen K.

doi:10.1016/j.mrfmmm.2005.01.016

Cited by 29 publications

(12 citation statements)

References 39 publications

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“…Previous report demonstrated that Scutellaria baicalensis is the main component in the herbal medicine Sho-saiko-to which is applied for the protection against hepatic fibrosis and carcinoma (Shimizu et al, 1999). Several studies indicated that Scutellaria baicalensis could effectively inhibit fibrosis and lipid peroxidation in rat liver (de Boer et al, 2005;Kim et al, 2010). However, the mechanisms underlying Scutellaria baicalensis mediated attenuation on HSCs proliferation have not been thoroughly investigated.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G2/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway

Pan

Wang

Leu

et al. 2012

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G2/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway

Pan

Wang

Leu

et al. 2012

Journal of Ethnopharmacology

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“…In recent years, some studies have been done on the effects of S. baicalensis extracts on CYP enzymes. The addition of S. baicalensis water extracts to the feed of F344 lacl transgenic BigBlue transgenic rats could increase the expression of the gene for glutathione S-transferase A5 subunit by 2.5 to 3.0-fold, and decrease expression of CYP3A2 by 1.8 to 2.0-fold (de Boer et al 2005). It is suggested that baicalein inhibited the formation of the aflatoxin metabolites AFBO and AFBM1, most likely through inhibition of CYP1A1 and 1A2 in rat liver microsomes (Kim et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes

Guo

et al. 2011

Eur J Drug Metab Pharmacokinet

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Wogonin, derived from the root of Scutellaria baicalensis, is a popular herb for its anticancer, anti-inflammatory, neuroprotective and anti-convulsant effects. The purpose of this study was to investigate the effect of wogonin on human hepatic cytochrome P450s (CYP450s) in vitro. Isoform-specific substrate probes of CYP1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 were incubated in human liver microsomes with or without wogonin. IC(50) and K (i) values were estimated and the types of inhibition were determined. Wogonin was a potent, competitive inhibitor of CYP1A2 (K (i) = 0.24 μM), and a weak inhibitor of CYP2C19 (IC(50) = 101.10 μM), but was not able to inhibit CYP2C9, CYP2D6, CYP2E1 and CYP3A4 (IC(50) > 200 μM). Wogonin could inhibit the activity of CYP1A2 and CYP2C19 with varying potency, while it is a strong inhibitor of CYP1A2. These findings suggested that it was necessary to study the potential pharmacokinetic drug interaction in vivo.

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“…S. baicalensis is the main component in the Japanese herbal medicine Sho‐saiko‐to, which is used as a protection against hepatic fibrosis and carcinoma (Shimizu, 2000). Some previous studies have suggested that S. baicalensis could provide hepato‐protection in animal models (de Boer et al ., 2005; Zhao et al ., 2006). Baicalin (Fig.…”

Section: Pharmacokinetic Application Of Herbal Medicines For the Treamentioning

confidence: 99%

Biological analysis of herbal medicines used for the treatment of liver diseases

Chien¹,

Wu²,

Tsai

2010

Biomedical Chromatography

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Herbal medicines have been used to treat liver disorders for thousands of years in the East and have now become a promising therapy internationally for pathological liver conditions. Biological analysis of hepatoprotective herbs is an important issue from the pharmacokinetic perspective in developing new therapeutic managements for liver disease. The biological analysis focuses on the pretreatment methods, separation and quantification of herbal medicines in biological samples. We have compiled and discuss the biological analytical method of six herbal medicines for liver protection containing Silybum marianum(silymarin), Glycyrrhiza glabra, Scutellaria baicalensis, Schisandra chinensis, Salvia miltiorrhiza and Astragalus membranaceus. This review provides a convenient reference for researchers to reduce time-consuming method optimization.

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Protection against aflatoxin-B1-induced liver mutagenesis by Scutellaria baicalensis

Cited by 29 publications

References 39 publications

Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G2/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway

Inhibitory effects of Scutellaria baicalensis extract on hepatic stellate cells through inducing G2/M cell cycle arrest and activating ERK-dependent apoptosis via Bax and caspase pathway

Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes

Biological analysis of herbal medicines used for the treatment of liver diseases

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