Protection Afforded by Sunscreens Containing Inorganic Sunscreening Agents Against Blue Light Sensitivity Induced by Aminolevulinic Acid

Bissonnette, Robert; Nigen, Simon; Bolduc, Chantal; Méry, Sophie; Nocera, Thérèse

doi:10.1111/j.1524-4725.2008.34311.x

Cited by 10 publications

(20 citation statements)

References 23 publications

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“…97,98 Attempts to utilize micronized zinc and titanium particles have resulted in improved skin appearance but decreased VLblocking capacity. 15,99,100 Early attempts to develop antioxidant-based VL sunscreens (ie, vitamin E cream) demonstrated no effects on VL-induced pigmentation, 101 while efforts of the use of antioxidant complexes showed less pigmentation immediately after VL irradiation compared to untreated sites but no statistically significant differences in pigmentation after 7 days. 13,60 More recently, Ezekwe et al 102 presented preliminary results demonstrating a significant decrease in clinical scores for hyperpigmentation at day 7 post-VL 1 UV-A1 irradiation using tinted organic sunscreen compared to an irradiated untreated control.…”

Section: Intelligent Design Of Next-generation Photoprotection Agains...mentioning

confidence: 99%

Impact of visible light on skin health: The role of antioxidants and free radical quenchers in skin protection

Lim

Kohli

Ruvolo³

et al. 2022

Journal of the American Academy of Dermatology

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Until recently, the primary focus of photobiology has centered on the impact of UV radiation on skin health, including DNA damage and oncogenesis; however, the significant effects of visible light (VL) on skin remain grossly underreported. VL has been reported to cause erythema in individuals with light skin (Fitzpatrick skin types [FSTs] I-III) and pigmentary changes in individuals with dark skin types (FSTs IV-VI). These effects have importance in dermatologic diseases and potentially play a role in conditions aggravated by sun exposure, including phototoxicity in patients with FSTs I to III and post-inflammatory hyperpigmentation and melasma in patients with FSTs IV to VI. The induction of free radicals, leading to the generation of reactive species, is one driving mechanism of VL-induced skin pathologies, leading to the induction of melanogenesis and hyperpigmentation. Initial clinical studies have demonstrated the effectiveness of topical sunscreen with antioxidant combinations in inhibiting VL 1 UV-A1-induced erythema in FSTs I to III and reducing pigmentation in FSTs IV to VI. Antioxidants may help prevent the worsening of pigmentary disorders and can be incorporated into photoprotective strategies. It is essential that dermatologists and the public are aware of the impact of VL on skin, especially in patients with skin of color, and understand the available options for VL protection.

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Section: Intelligent Design Of Next-generation Photoprotection Agains...mentioning

confidence: 99%

Impact of visible light on skin health: The role of antioxidants and free radical quenchers in skin protection

Lim

Kohli

Ruvolo³

et al. 2022

Journal of the American Academy of Dermatology

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“…Blue light irradiation increased melanin production, oxygen saturation, and hemoglobin content in female volunteers [29]. Skin darkening and erythema have also been observed after exposure to blue light [29, 34].…”

Section: Introductionmentioning

confidence: 99%

“…Most currently available sunscreens are designed to protect against UV radiation, and organic sunscreen agents predominantly absorb UVB radiation [34]. Tinted sunscreens that contain inorganic compounds such as iron oxides, titanium dioxide, and zinc oxide are able to provide protection against blue light radiation [34, 45].…”

Section: Introductionmentioning

confidence: 99%

“…Lastly, there is a lack of a widely adopted indicator of the ability of sunscreens to protect against blue light radiation. The sun protection factor (SPF), a common marker of sunscreen effectiveness, primarily reflects the UVB protection level [34]. The SPF shows how much energy is required to produce sunburn on sunscreen-protected skin compared with unprotected skin.…”

Section: Introductionmentioning

confidence: 99%

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Direct and Indirect Effects of Blue Light Exposure on Skin: A Review of Published Literature

Suitthimeathegorn

Cheng

et al. 2022

Skin Pharmacol Physiol

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The growing use of electronic devices and other artificial light sources in recent decades has changed the pattern of exposure to blue light (400–500 nm). Although some progress has been made in the study of the biological effects of blue light on the skin, many questions in this field remain unexplored. The aim of this article was to review the currently available evidence on the deleterious effects of blue light on the skin, as well as the methods and strategies designed to protect from the detrimental effects of blue light. PubMed and ProQuest databases were searched in January 2022. Search results were supplemented by articles considered relevant by the authors. The results of in vitro, in vivo and clinical studies show that blue light produces direct and indirect effects on the skin. The most significant direct effects are the excessive generation of reactive oxygen and nitrogen species, and hyperpigmentation. Reactive oxygen and nitrogen species cause DNA damage and modulate the immune response. Indirect effects of blue light include disruption of the central circadian rhythm regulation via melatonin signaling and local circadian rhythm regulation via direct effects on skin cells. Antioxidants and sunscreens containing titanium dioxide, iron oxides, and zinc oxide can be used to protect against the detrimental effects of blue light as part of a strategy that combines daytime protection and night-time repair. Blue light produces a wide variety of direct and indirect effects on the skin. As exposure to blue light from artificial sources is likely to continue to increase, this area warrants further investigation.

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“…Perhaps the most critical unanswered question is what is causing the lower rate of side effects—the liposomal vehicle, the low concentration of ALA, the short contact with the skin, or the choice of intense pulsed light? And what is the rate of severe side effects with good sun protection 12 versus complete avoidance?…”

mentioning

confidence: 99%

Commentary: How Do We Achieve Consistent Reproducible and Clinically Relevant Results with PDT for Acne?

Taub

2011

Dermatologic Surgery

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Protection Afforded by Sunscreens Containing Inorganic Sunscreening Agents Against Blue Light Sensitivity Induced by Aminolevulinic Acid

Abstract: The sunscreen containing iron oxide 3.2% afforded significant protection against blue light sensitivity induced by ALA application.

Cited by 10 publications

References 23 publications

Impact of visible light on skin health: The role of antioxidants and free radical quenchers in skin protection

Impact of visible light on skin health: The role of antioxidants and free radical quenchers in skin protection

Direct and Indirect Effects of Blue Light Exposure on Skin: A Review of Published Literature

Commentary: How Do We Achieve Consistent Reproducible and Clinically Relevant Results with PDT for Acne?

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