Protecting Indian schoolchildren against rabies: Pre-exposure vaccination with purified chick embryo cell vaccine (PCECV) or purified verocell rabies vaccine (PVRV)

30 years of rabies vaccination with Rabipur: a summary of clinical data and global experience

“…No serious adverse events (SAEs) were reported after vaccination [57]. Another study (n = 175) comparing three IM doses of Rabipur (reconstituted in 1.0 ml or 0.5 ml diluent) or PVRV with single doses on Days 0, 7 and 28 for PrEP in children aged 6-13 years demonstrated that RVNA concentrations were ‡0.5 IU/ml by Day 49 [58]. Similar findings have been observed in children aged 12-18 months receiving IM or ID Rabipur (1.0 or 0.1 ml, respectively) on Days 0,7 and 28 for PrEP, with concomitant administration of Japanese encephalitis vaccine [59].…”

“…Two hundred and seventy one children aged 1-13 years No SAEs [58] PrEP IM 3-dose (1.0 ml) PrEP IM 3-dose (0. …”

Update on Available Vaccines in India: Report of the APPA VU 2010: I

“…The WHO pre-qualified vaccines such as the purified chick embryo cell vaccine (PCECV) or the purified verocell rabies vaccine (PVRV) are safe and immunogenic when administered intramuscularly for preexposure prophylaxis of rabies in children [11]. They are administered as a three-dose intramuscular (given on deltoid muscle) pre-exposure regimen on days 0, 7 and 28 [10,11].…”

“…They are administered as a three-dose intramuscular (given on deltoid muscle) pre-exposure regimen on days 0, 7 and 28 [10,11]. According to the current WHO recommendations, in case of an exposure to rabies only two additional doses of rabies vaccine are necessary (on days 0 and 3 post-exposure) for protection of those who have previously received a complete pre-exposure immunization course, and, most importantly, in such patients no rabies immunoglobulin administration is required for Category III wounds [10,12].…”

Rabies pre-exposure vaccination of children with purified chick embryo cell vaccine (PCECV)

“…The safety and immunogenicity of rabies vaccine was examined when administered IM to 175 children 3 to 12 y of age. 28 Either PCECV or a purified Vero cell rabies vaccine (PVRV) was given on days 0, 7 and 28 reconstituted in different volumes (1 mL or 0.5 mL PCECV, group A or B, or 0.5 mL PVRV, group C; per protocol population n = 57, 58, and 55, respectively). In all groups, the children developed VNA concentrations above 0.5 IU/mL by day 49.…”