Protecting group-free synthesis of the fungicide Mandipropamid

Abstract

A simple and efficient protecting group free synthesis of a relatively new fungicide Mandipropamid has been achieved in five steps, with an excellent overall yield. The synthesis started from commercially available starting materials like vanillin and p-chloroacetophenone. The key steps involved in the synthesis are the Henry and Cannizzaro reactions, as well as amide formation through a carboxylic acid-amine coupling step.