“…Recently, we have successfully demonstrated protecting group-controlled regioselective functionalization of 3,5-dibromo-2-pyridones. [15] The p-toluenesulfonyl (Ts) group was employed for the continuousflow regioselective C3 functionalization of 3,5-dibromo-2-pyridones. After regioselective halogen-lithium exchange (HLE) of 3,5-dibromo-2-tosyloxypyridine, various electrophiles such as N,N-dimethylformamide (DMF), weinreb amide, aldehydes, ketone, chlorotrimethylsilane, and p-toluenesulfonyl cyande (TsCN) were used to quench the resulting orgnolithium reagent.…”