Protecting from Candida albicans

Crunkhorn, Sarah

doi:10.1038/nrd.2016.169

Cited by 10 publications

(6 citation statements)

References 2 publications

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“…Structure was solved with the aid of SHELXT [16,17]. The 2-furylring is disordered over two sites with an occupancy ratio of 0.68 (4):0.32 (4). SIMU, DELU and SAME restraints were used to model this disordered molecule.…”

Section: Crystal Structure Determinationmentioning

confidence: 99%

“…The development of drug-resistance and high morbidity rates due to life-threatening fungal infections increased dramatically during the last few decades and they account for a major global health problem [1,2]. Individuals with autoimmune diseases, organ transplants, acquired immunodeficiency syndrome (AIDS) or cancer are particularly more susceptible to life-threatening fungal infections than others [3,4]. The number of the available antifungal drugs is limited which could be attributed to the eukaryotic nature of the fungal's cell which restricts the number of theantifungal drugs that can target fungal's cell over human hosts [5].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Single Crystal X-ray Structure, DFT Computations, Hirshfeld Surface Analysis and Molecular Docking Simulations on ({[(1E)-1-(1,3-Benzodioxol-5-yl)-3-(1H-imidazol-1-yl)propylidene]amino}oxy)(furan-2-yl)methanone: A New Antifungal Agent

Al-Wabli

Al-Ghamdi

Aswathy³

et al. 2019

Crystals

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The development of drug-resistance and high morbidity rates due to life-threatening fungal infections account for a major global health problem. A new antifungal imidazole-based oximino ester 5 has been prepared and characterized with the aid of different spectroscopic tools. Single crystal X-ray analysis doubtlessly identified the (E)-configuration of the imine fragment of the title compound. Compound 5, C18H15N3O5, was crystallized in the monoclinic, P21/c, a = 10.4067 (5) Å, b = 6.8534 (3) Å, c = 23.2437 (12) Å, β = 94.627 (2)°, V = 1652.37 (14) Å3, Z = 4. Spectral and electronic features of compound 5 have been thoroughly explored with the aid of density function theory (DFT) simulations and the data were compared with the experimental results. In addition, Hirshfeld surface analysis and molecular docking simulations were executed on the target compound. Molecular docking results are fairly consistent with the experimental in vitro antifungal potential of the oximino ester 5.

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Section: Crystal Structure Determinationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, Single Crystal X-ray Structure, DFT Computations, Hirshfeld Surface Analysis and Molecular Docking Simulations on ({[(1E)-1-(1,3-Benzodioxol-5-yl)-3-(1H-imidazol-1-yl)propylidene]amino}oxy)(furan-2-yl)methanone: A New Antifungal Agent

Al-Wabli

Al-Ghamdi

Aswathy³

et al. 2019

Crystals

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“…As the increasing population of immunocompromised individuals, such as those suffering from human immunodeficiency virus (HIV) infection, chemotherapy, radiotherapy, and organ transplantation, the infections by opportunistic fungal pathogens are becoming severe and global issues. These infections are attributed to the defect of immune response in these patients against the pathogens [1][2][3]. The fungal infections frequently contribute to hospital-acquired infection-related death [4].…”

Section: Introductionmentioning

confidence: 99%

Phospholipid/protein co-mediated assembly of Cu2O nanoparticles for specific inhibition of growth and biofilm formation of pathogenic fungi

Wei

Tian

et al. 2020

Sci. China Mater.

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As the increasing number of the individuals suffering from AIDs, chemotherapy, and radiotherapy, pathogenic fungi, which may rapidly grow and invade the host tissues in these immune-compromised patients, is becoming great threat to human health. In this study, we constructed a novel fungal pathogen-responsive assembly of cuprous oxide (Cu 2 O) nanoparticles (NPs) for specific targeting and inhibiting growth and biofilm formation of the representative fungal pathogen, Candida albicans (C. albicans). This assembly was formed by coating the initial Cu 2 O NPs with both phosphatidylethanolamine (PE) and bovine serum albumin (BSA), followed by hydrophobic/electrostatic interaction-driven formation of the Cu 2 O-PE-BSA microaggregates. The formed microaggregates could be induced for disassembly by the fungal pathogen C. albicans, leading to close binding of the NPs to the cell wall of the pathogen. Both confocal microscopy and viability assays showed that the assembly strongly inhibited growth and biofilm formation of the pathogen, but had extreme low toxicity to mammalian cells. In vivo mouse wound model further revealed that the assembly had high capacity of healing the fungus-infected wounds and reduced the fungal burden of the wound tissues. This study sheds a novel light on facile development of pathogen-responsive nano-assemblies for efficient and safe antifungal therapy.

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“…The extent of life-threatening fungal infections has increased remarkably during the last three decades. Drug-resistance to the available antifungal agents and increasing morbidity due to life-threatening fungal infections have become a global health burden, particularly among individuals with organ transplants, AIDS, autoimmune diseases or those receiving anticancer chemotherapeutic agents [1,2,3,4]. Therefore, there is an urgent therapeutic need to develop new broad spectrum safe antifungal candidates with excellent activity toward various pathogenic fungi.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Spectroscopic Identification of Certain Imidazole-Semicarbazone Conjugates Bearing Benzodioxole Moieties: New Antifungal Agents

et al. 2019

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During the last three decades the extent of life-threatening fungal infections has increased remarkably worldwide. Synthesis and structure elucidation of certain imidazole-semicarbazone conjugates 5a–o are reported. Single crystal X-ray analysis of compound 5e unequivocally confirmed its assigned chemical structure and the (E)-configuration of its imine double bond. Compound 5e crystallized in the triclinic system, P-1, a = 6.3561 (3) Å, b = 12.5095 (8) Å, c = 14.5411 (9) Å, α = 67.073 (4)°, β = 79.989 (4)°, γ =84.370 (4)°, V = 1048.05 (11) Å3, Z = 2. In addition, DIZ and MIC assays were used to examine the in vitro antifungal activity of the title conjugates 5a–o against four fungal strains. Compound 5e, bearing a 4-ethoxyphenyl fragment, showed the best MIC value (0.304 µmol/mL) against both C. tropicalis and C. parapsilosis species, while compounds 5c (MIC = 0.311 µmol/mL), 5k, and 5l (MIC = 0.287 µmol/mL) exhibited the best anti-C. albicans activity.

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Protecting from Candida albicans

Cited by 10 publications

References 2 publications

Synthesis, Single Crystal X-ray Structure, DFT Computations, Hirshfeld Surface Analysis and Molecular Docking Simulations on ({[(1E)-1-(1,3-Benzodioxol-5-yl)-3-(1H-imidazol-1-yl)propylidene]amino}oxy)(furan-2-yl)methanone: A New Antifungal Agent

Synthesis, Single Crystal X-ray Structure, DFT Computations, Hirshfeld Surface Analysis and Molecular Docking Simulations on ({[(1E)-1-(1,3-Benzodioxol-5-yl)-3-(1H-imidazol-1-yl)propylidene]amino}oxy)(furan-2-yl)methanone: A New Antifungal Agent

Phospholipid/protein co-mediated assembly of Cu2O nanoparticles for specific inhibition of growth and biofilm formation of pathogenic fungi

Synthesis and Spectroscopic Identification of Certain Imidazole-Semicarbazone Conjugates Bearing Benzodioxole Moieties: New Antifungal Agents

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