Protected Mercaptoalkylpyrimidinones: Synthesis and Test for Immunostimulating Activity.

Abstract

Pyrimidine derivatives R 0510 Protected Mercaptoalkylpyrimidinones: Synthesis and Test for Immunostimulating Activity. -Compounds (IV) and (VIa) both show immunostimulating activity, while compound (VIb) surprisingly shows no activity. -(BRIEL*, D.; DROESSLER, K.; RYBAK, A.; HOLZER, M.; DOBNER, B.; Pharmazie 60 (2005) 6, 415-417; Inst. Pharm. Pharm.

Synthesis and oxidation of sulfides containing an isocyanurate fragment

“…More than a hundred compounds 2 con taining a sulfur atom in the structure are used as medicinal agents, and the search in this direction is still under inten sive way. [3][4][5][6][7][8][9] Among different classes of sulfur containing organic compounds, the substances possessing antituberculosis, 3 antidiabetes, 4 and immunomodulating 5 activities, tran quilizers, 6 and enzymes inhibitors 7,8 were discovered. Modaphinil (2 benzhydrylsulfinylacetamide) is widely used for treatment of narcolepsy, the Parkinson and Alzhei mer diseases, depressions, multiple sclerosis, and other diseases.…”