2000
DOI: 10.1042/bst028a284a
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Proteasomes regulate the duration of erythropoietin receptor activation by controlling down-regulation of cell surface receptors

Abstract: The earliest second messenger discovered was the CAMP. cAMP weakly penetrates into the cell. O n the other hand, dibutyryl cAMP is membrane-penetratible derivative of the CAMP, which shows high activity and at present time is largerly used in experiments.The comparative study of the effects of cAMP and dibutyryl cAMP on the structure of monoolein-water cubic liquid-crystalline phase have been performed by X-ray diffraction, Raman, and FTIR spectroscopies. Based on the X-ray diffraction data it was established … Show more

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Cited by 7 publications
(13 citation statements)
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“…The proteasome complex prevents the renewal of surface EPOR by inhibiting the insertion of newly‐synthesized EPOR into the cell membrane (Verdier et al , ). The main signal for proteasomal degradation is lysine‐related ubiquitination.…”
Section: Discussionmentioning
confidence: 99%
“…The proteasome complex prevents the renewal of surface EPOR by inhibiting the insertion of newly‐synthesized EPOR into the cell membrane (Verdier et al , ). The main signal for proteasomal degradation is lysine‐related ubiquitination.…”
Section: Discussionmentioning
confidence: 99%
“…Several factors may determine both the concentration and temporal parameters that regulate the neuroprotective ability of EPO. During chronic administration, EPO can result in the formation of anti EPO antibodies (Casadevall et al ., 2002) and decrease the expression of the EPOR on the cell surface (Verdier et al ., 2000). As a result, biological function of EPO can be blocked at any concentration level.…”
Section: Discussionmentioning
confidence: 99%
“…For example, the erythropoietin receptor (EpoR) and its downstream signaling molecules, or the interleukin (IL)-2 and IL-9 receptors, were shown to be regulated by the proteasome (478). Although the rate of EpoR internalization is not affected, receptor recycling is enhanced in the presence of proteasome inhibitors, suggesting the proteasome is involved in EpoR sorting (441). Moreover, downstream effectors of EpoR and other cytokine receptors are regulated by ubiquitylation as well.…”
Section: Other Cytokine Receptorsmentioning
confidence: 97%