Abstract:Introduction
The ubiquitin-proteasome system (UPS) is crucial for cellular protein homeostasis by ensuring the degradation of redundant or misfolded proteins. As a result, the UPS plays a key role in the regulation of multiple cellular processes, including erythropoiesis, where the proteasome is essential for erythroid expansion and differentiation. The UPS is also of major importance in terminal maturation to erythrocytes, by regulating the degradation of ribosomal proteins (Nguyen et al, Scien… Show more
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