Proteasome Fate in Aging and Proteinopathies

Healthspan improvement and anti-aggregation effects induced by a marine-derived structural proteasome activator

“…Likewise, proteasome activation through a triterpene, namely 18α-glycyrrhetinic acid (18α-GA), conferred resistance to Aβ-induced proteotoxicity in various AD nematode models, as well as to murine cortical neurons exogenously supplemented with enhanced concentrations of Aβ peptide [ 17 ]. Similar positive results have also been observed for other natural compounds in various AD models [ 24 , 25 ].…”

“…It is increasingly accepted that proteasome activation may act protectively against the progression of various proteinopathies [ 25 , 65 ]. This is not surprising as diminished proteasome activity and reduced protein expression levels of various proteasome subunits have been detected in various in vitro and in vivo AD models, as well as in the brain samples of AD patients [ 66 , 67 ].…”