Proteasomal activity in brain tissue following ischemic stroke in Wistar rats

Savchuk, O.; Orlovsky, M.O.; Гончаров, С. В.; Dosenko, V.E.; Skibo, G. G.

doi:10.15407/fz61.05.011

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…After transient cerebral ischemia, the depletion of ubiquitin and the accumulation of its mutant form (ubiquitin(+1)) may inhibit the ubiquitin-proteasome pathway, which results in delayed neuronal death of CA1 pyramidal neurons directly or indirectly [13]. Meanwhile, proteasome activity may play a role in contralateral cortical plasticity occurring after focal cerebral ischemia [14]. Proteasome subunit type 6 (PSMA6) gene polymorphisms are associated with susceptibility to ischemic stroke, while PSMA6 (-C8G) gene polymorphism may play a protective role with the susceptibility of ischemic stroke [15].…”

Section: The Role Of the Ubiquitin-proteasome Pathway Inmentioning

confidence: 99%

The Role of Ubiquitin-Proteasome Pathway and Autophagy-Lysosome Pathway in Cerebral Ischemia

Chen

Qin

Tan

et al. 2020

Oxidative Medicine and Cellular Longevity

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The ubiquitin-proteasome pathway and autophagy-lysosome pathway are two major routes for clearance of aberrant cellular components to maintain protein homeostasis and normal cellular functions. Accumulating evidence shows that these two pathways are impaired during cerebral ischemia, which contributes to ischemic-induced neuronal necrosis and apoptosis. This review aims to critically discuss current knowledge and controversies on these two pathways in response to cerebral ischemic stress. We also discuss molecular mechanisms underlying the impairments of these protein degradation pathways and how such impairments lead to neuronal damage after cerebral ischemia. Further, we review the recent advance on the understanding of the involvement of these two pathways in the pathological process during many therapeutic approaches against cerebral ischemia. Despite recent advances, the exact role and molecular mechanisms of these two pathways following cerebral ischemia are complex and not completely understood, of which better understanding will provide avenues to develop novel therapeutic strategies for ischemic stroke.

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Section: The Role Of the Ubiquitin-proteasome Pathway Inmentioning

confidence: 99%