Proteases

Deraison, Céline; Bonnart, Chrystelle; Vergnolle, Nathalie

doi:10.1002/9783527692156.ch28

Cited by 3 publications

(7 citation statements)

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“…[23] In the human and animal body, proteases are secreted by a variety of cells, including inflammatory cells, such as neutrophils, macrophages, and mast cells, as well as non-inflammatory cells, such as epithelial cells, endothelial cells, keratinocytes, and fibroblasts. [24] The following paragraph briefly reviews some roles of proteases whose names have been mentioned in the current article; it is not an exhaustive review; interested readers could refer to other review articles [25][26][27][28][29][30][31] to get more insights on this topic. However, it should be noted that hardly any proven mechanism for the modes of action of proteases in wound healing could be found.…”

Section: Proteases Their Origins and Functionsmentioning

confidence: 99%

“…[42] Plasmin can activate a variety of MMPs and also contributes to the liberation of transforming growth factor-beta (TGF-𝛽) from the matrix. [24] Granzyme B, which is produced by a wide variety of cells, especially T lymphocytes and natural killer cells, plays different roles; one of the well-known ones is key functions in cell apoptosis. [43,44] Figure 1 schematically presents certain consequences of protease activities relevant to the wound-healing process.…”

Section: Proteases Their Origins and Functionsmentioning

confidence: 99%

“…[41] Endothelial cells are held together by a protein called E-cadherin, which forms a tight seal between them; neutrophil elastase and cathepsin G can break the junctions and enable neutrophils to squeeze through the gaps and reach the inflamed tissue. [24] Plasminogen is transformed into plasmin by urokinase plasminogen activators. [42] Plasmin can activate a variety of MMPs and also contributes to the liberation of transforming growth factor-beta (TGF-𝛽) from the matrix.…”

Section: Proteases Their Origins and Functionsmentioning

confidence: 99%

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Approaches to Control and Monitor Protease Levels in Chronic Wounds

Kolahreez,

Ghasemi‐Mobarakeh,

Liebner

et al. 2024

Advanced Therapeutics

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Some wounds do not follow the typical healing trajectory and show very little, if any, progress. They dreadfully threaten the patients' quality of life and may even lead to limb amputation and death. Several interrelated systemic and local factors may cause a delay in wound healing. The microenvironment of these wounds could be different from wounds that heal spontaneously or with standard treatment. As discussed in the present work, proteases’ levels or activity could be elevated in some cases of chronic ulcers; infection could aggravate the situation. A detailed overview of the proteases’ effect on wound healing is presented in this paper. Assuming untimely or irregularly excessive proteolytic activity plays a pathological role, some researchers targeted attenuation of protease level as a strategy to promote healing. This could be done via different approaches, including physical removal, inhibiting their activity, and controlling their expression directly through gene silencing or indirectly, for instance, by resolving infection. Apart from targeting protease modulation as a therapeutic strategy, many studies have examined the protease state to gain insights into the underlying mechanisms by which a remedy, dressing, or specific therapy has affected the healing process. This article aims to provide an overview of the studies in these two categories. Of course, various proteases are involved in the healing process, but in each study, usually, only one or some of them were investigated; matrix metalloproteinase‐2 (MMP‐2), MMP‐9, and human neutrophil elastase (HNE) are among them. Furthermore, in some cases, cumulative proteolytic activity has been evaluated in terms of gelatinolytic, collagenolytic, or caseinolytic activity, which is also absolutely beneficial. Some research groups have considered the potential of proteases as a diagnostic or prognostic biomarker and have tried to develop some sensors or indicators; this topic has also been covered in the present work.This article is protected by copyright. All rights reserved

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Section: Proteases Their Origins and Functionsmentioning

confidence: 99%

Section: Proteases Their Origins and Functionsmentioning

confidence: 99%

Section: Proteases Their Origins and Functionsmentioning

confidence: 99%

See 1 more Smart Citation

Approaches to Control and Monitor Protease Levels in Chronic Wounds

Kolahreez,

Ghasemi‐Mobarakeh,

Liebner

et al. 2024

Advanced Therapeutics

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“…[88]. The host inflammatory response is accompanied by release of proteases from neutrophil granulocytes, macrophages and mast cells.…”

Section: Proteases and Diseasementioning

confidence: 99%

“…A comprehensive, recent overview of protease activity in inflammation is given by Deraison et al . [88]. The host inflammatory response is accompanied by release of proteases from neutrophil granulocytes, macrophages and mast cells.…”

Section: Proteases and Diseasementioning

confidence: 99%

Proteases: Pivot Points in Functional Proteomics

Verhamme

Leonard

Perkins

2018

Functional Proteomics

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Proteases drive the life cycle of all proteins, ensuring the transportation and activation of newly minted, would-be proteins into their functional form while recycling spent or unneeded proteins. Far from their image as engines of protein digestion, proteases play fundamental roles in basic physiology and regulation at multiple levels of systems biology. Proteases are intimately associated with disease and modulation of proteolytic activity is the presumed target for successful therapeutics. “Proteases: Pivot Points in Functional Proteomics” examines the crucial roles of proteolysis across a wide range of physiological processes and diseases. The existing and potential impacts of proteolysis-related activity on drug and biomarker development are presented in detail. All told the decisive roles of proteases in four major categories comprising 23 separate sub-categories are addressed. Within this construct, 15 sets of subject-specific, tabulated data are presented that include identification of proteases, protease inhibitors, substrates and their actions. Said data are derived from and confirmed by over 300 references. Cross comparison of datasets indicates that proteases, their inhibitors/promoters and substrates intersect over a range of physiological processes and diseases, both chronic and pathogenic. Indeed, “Proteases: Pivot Points …” closes by dramatizing this very point through association of (pro)Thrombin and Fibrin(ogen) with: hemostasis, innate immunity, cardiovascular and metabolic disease, cancer, neurodegeneration and bacterial self-defense.

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