Protease inhibitor associated mutations compromise the efficacy of therapy in human immunodeficiency virus – 1 (HIV-1) infected pediatric patients: a cross-sectional study

Abstract

Background: Although the introduction of combined therapy with reverse transcriptase and protease inhibitors has resulted in considerable decrease in HIV related mortality; it has also induced the development of multiple drug-resistant HIV-1 variants.

Treatment Response in Association with Adherence Patterns to Highly Active Antiretroviral Therapy in Pediatric Patients with Perinatally Acquired HIV Infection

“…We found that the immunologic response in the majority of patients was in the persistent nonsuppression category and was not associated with adherence patterns. Previously in our cross-sectional study, 21 we had also not found an association between the high level of virus production and severity of CD4 count depletion in children with HIV. Resino et al 22 showed that VL suppression is not necessary for recovery of CD4 counts.…”