Protease activities of Candida spp. isolated from immunocompetent patients with otomycosis

Arsenijevic-Arsic, Valentina; Arsović, Nenad; Dzamic, M Aleksandar; Trpković, Ana; Zec-Kranjcic, Ivana; Djukić, Vojko

doi:10.2298/jmh0402171a

Cited by 5 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Protease produced by Candida species is implicated in the pathogenesis of Candida-caused otomycosis, according to research. This enzyme is involved in the colonization of Candida species on the skin and ears [20].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Prevalence of Otomycosis in Patients Referred to the ENT Clinic

Merza¹,

Abdulkhaleq²

2021

IJOHNS

View full text Add to dashboard Cite

Objective: Otomycosis is a common fungal infection of the outer ear that is seen in tropical and subtropical regions of the world. This disease is one of the common problems that ENT specialists, face. Therefore, this study was conducted to evaluate the status and frequency of this disease in patients referred to the ENT clinic of Salmaniya Medical Complex, Kingdom of Bahrain for one year (2019)(2020). Materials & Methods: Thirty-five patients (23 males and 12 females) were mycologically examined with a clinical diagnosis of otomycosis. In order to diagnose the disease, first ear sampling done and then the collected samples directly tested with 10% KOH and culture of samples was performed on Saburo dextrose agar and Saburo dextrose agar containing chloramphenicol. In order to determine the fungus species, various laboratory methods and differential tests were used. Results: In this study, out of 56 patients with clinical diagnosis of otomycosis, according to laboratory results, only 38 patients (67.8%) were diagnosed with otomycosis. Of these, 18 patients (32.1%) were male and 20 (35.7%) were female. The highest number of cases was observed in the age group of 30 -40 years. Isolated fungal agents were: Aspergillus niger 24 cases (63.1%), Candida albicans 9 cases (23.7%), Aspergillus fumigatus 2 cases (5.3%), Aspergillus glaucous 2 cases (5.3%), and Penicillium one case (2.6%). Conclusion: In this study, the most common fungi isolated from patients with otomycosis were Aspergillus and Candida species, which is consistent with other studies. The present study showed, otomycosis cannot be diagnosed by clinical symptoms alone and it requires laboratory diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of the Prevalence of Otomycosis in Patients Referred to the ENT Clinic

Merza¹,

Abdulkhaleq²

2021

IJOHNS

View full text Add to dashboard Cite

show abstract

“…According to studies, a protease secreted by Candida species is involved in the pathogenesis of Candida-caused otomycosis. This enzyme is implicated in Candida genus colonisation of the ears and skin 12 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Otomycosis: An Evaluation among Patients Visiting ENT Clinics

Wakeel¹,

Tariq²,

Gul³

et al. 2021

PJMHS

View full text Add to dashboard Cite

Aim: To look at the relative frequency and prevalence of the otomycosis in individuals visited ENT department of Bahawal Victoria hospital, Bahawalpur. Methodology: It was a cross-sectional study conducted at ENT department of Bahawal Victoria Hospital, Bahawalpur during 2019-2020. Forty-Two individuals (27 males and 15 females) with a diagnosis of otomycosis on clinical basis were mycologically investigated. To diagnose the condition, ear samples were taken and immediately examined using 10% KOH, followed by culture on Saburo dextrose agar plus Saburo dextrose agar also having chloramphenicol. Different laboratory approaches and differential testing were utilized to determine the kind of fungal species. Ethical approval was taken from Ethical review board of Bahawal Victoria Hospital, Bahawalpur. SPSS version 25 was used for data analysis. Results: Only 42 individuals (66.6%) were identified with otomycosis in this research based on laboratory data, out of 63 people undergoing a clinical diagnosis of otomycosis There were 27 male participants (42.8%) and 15 female participants (23.8%) among them. Penicillium, Aspergillus glaucous, Aspergillus fumigates, Candida albicans and Aspergillus niger have 1 (1.5%), 3 (4.7%), 3 (4.7%), 9 (14.6%) and 26 (41.2%) cases respectively. Conclusion: The most prevalent fungus identified was Aspergillus and Candida species. Key Words: Otomycosis, Aspergillus niger, Candida albicans

show abstract

Protease activities of Candida spp. isolated from otitis externa: Preliminary result

Arsović¹,

Banko

Dimitrijevic

et al. 2009

ACTA CHIR IUG

View full text Add to dashboard Cite

Otomycosis is a fungal infection of the ear predominantly caused by Candida and Aspergillus spp. The possible virulence factors of Candida spp. are enzymes, such as proteases, phospholipases, phosphatases and esterase. According to our knowledge, protease production in Candida strains isolated from patients with otomycosis has not been investigated. The present study was aimed at determining in vitro protease activity in 8 strains of Candida spp. (C. parapsilosis, C. famata, C. guilliermondii and C. albicans) isolated from children with otomycosis. A majority of isolated strains 7/8 (87.5%) were protease positive. The protease activity ranged from Pz 0.61 to 0.78. Further investigation is necessary to clarify the contribution of protease production to Candida virulence associated with otomycosis.

show abstract

Protease activities of Candida spp. isolated from immunocompetent patients with otomycosis

Cited by 5 publications

References 14 publications

Evaluation of the Prevalence of Otomycosis in Patients Referred to the ENT Clinic

Evaluation of the Prevalence of Otomycosis in Patients Referred to the ENT Clinic

Prevalence of Otomycosis: An Evaluation among Patients Visiting ENT Clinics

Protease activities of Candida spp. isolated from otitis externa: Preliminary result

Contact Info

Product

Resources

About