“…An “autocatalytic” decline in control of protein quality is also indicated by observation that whereas initiation of lens early opacities takes decades, progression to debilitating cataracts frequently occurs during just a few years. This age‐related accumulation and acceleration toward lesion is consistent with the age‐related decline in UPP capability, particularly the proteolytic component of the UPP (36, 77). The accumulation of protein aggregates that contain oxidatively modified proteins with ubiquitin conjugates also disrupt function in many other cell types, including premature aging syndromes, age‐related diseases such as age‐related maculopathy, the amyloid diseases, including Alzheimer's, Parkinson's and ALS, ataxias and other neurodegenerative disorders, diabetes, and some cancers (24, 64, 66, 74, 78, 79).…”