Protease activated receptor-4: ready to be part of the antithrombosis spectrum
Izabella Andrianova,
Mia Kowalczyk,
Frederik Denorme
Abstract:Purpose of review
Cardiovascular disease is a major cause of death worldwide. Platelets play a key role in this pathological process. The serine protease thrombin is a critical regulator of platelet reactivity through protease activated receptors-1 (PAR1) and PAR4. Since targeting PAR4 comes with a low chance for bleeding, strategies blocking PAR4 function have great antithrombotic potential. Here, we reviewed the literature on platelet PAR4 with a particular focus on its role in thromboinflammatio… Show more
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