Protamine 2 Deficiency Results In Septin 12 Abnormalities
Ondrej Sanovec,
Michaela Frolikova,
Veronika Kraus
et al.
Abstract:There is a well-established link between abnormal sperm chromatin states and poor motility, however, how these two processes are interdependent is unknown. Here, we identified a possible mechanistic insight by showing that Protamine 2, a nuclear DNA packaging protein in sperm, directly interacts with cytoskeletal protein Septin 12, which is associated with sperm motility. Septin 12 has several isoforms, and we show, that in thePrm2-/-sperm, the short one (Mw 36 kDa) is mislocalized, while two long isoforms (Mw… Show more
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