Prosthetic Valve Endocarditis Caused by Brucella melitensis

Fernández-Guerrero, Manuel L.; Martinell, J.; Aguado, José María; Ponte, María del Carmen; Fraile, J.; Rábago, Gregorio

doi:10.1001/archinte.1987.00370060137022

Cited by 27 publications

(3 citation statements)

References 15 publications

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“…Brucella endocarditis produces highly destructive lesions of the valve structures 19.20 . Although a complete cure can be occasionally achieved with medical treatment alone 22,23 , most require surgical treatment because of hemodynamic instability 19,20,22 . Although overall mortality from brucellosis is low, endocarditis is a severe complication and accounts for about 80% of deaths 24 .…”

Section: Discussion:-mentioning

confidence: 99%

Title Page: Brucella Endocarditis: From Non-Endemic Area: A Case Report.

M.N¹,

Kumar²,

Mahale³

et al. 2016

IJAR

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Brucellosis is an anthropozoonosis caused by Brucella melitensis, B.abortus, B.suis and few other species of Brucella. It has worldwide distribution. It can be asymptomatic infection on one hand and the other hand it can cause serious debilitating disease, if left untreated can be fatal. We hereby report a case of Brucellosis with endocarditis as a complication and multisystem involvement which proved to be fatal in spite of treatment.

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Section: Discussion:-mentioning

confidence: 99%

Title Page: Brucella Endocarditis: From Non-Endemic Area: A Case Report.

M.N¹,

Kumar²,

Mahale³

et al. 2016

IJAR

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“…Three patients were treated with a single drug, while the others were treated with a combination of 2 or more antibiotics. The combination of tetracycline or cotrimoxazole with streptomycin was used in 10 patients [5,7,10,12,14,15,17] and the combination of cotrimoxazole, tetra cycline and streptomycin in 4 patients [19], Tetracycline, streptomycin and rifampicin were used in 2 patients [8,16]. Cardiac sur gery was performed for heart failure in 20 patients and for persistent fever and/or new vegetations despite medical therapy in 3 pa tients.…”

Section: Discussionmentioning

confidence: 99%

“…Cardiac sur gery was performed for heart failure in 20 patients and for persistent fever and/or new vegetations despite medical therapy in 3 pa tients. Two patients were operated on twice due to infection of the implanted valve [ 17]. Two patients died during the acute phase of the disease [4,5].…”

Section: Discussionmentioning

confidence: 99%

Brucellosis in Patients with Heart Disease: When Should Endocarditis Be Diagnosed?

Flugelman¹,

Galun²,

Ben-Chétrit³

et al. 1990

Cardiology

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Three patients, 2 with congenital valvular heart disease and 1 with a prosthetic aortic valve developed brucellosis. Brucella melitensis was isolated from blood of all 3 patients. The clinical and microbiological fetures suggested Brucella endocarditis and following successful antibiotic therapy, no surgery was required. The salient diagnostic features are discussed with emphasis on the management and prognosis of patients with Brucella endocarditis.

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Conservative treatment for brucella endocarditis

Cohen¹,

Golik²,

Alon³

et al. 1997

Clinical Cardiology

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Summary:Endocarditis is the most devastating complication of brucellosis. The accepted treatment for Brucella endocarditi\ (BE) is a combination of valve replacement and antibiotics. Concervative antibiotic treatment alone is not recommended by most authors, as it is considered ineffective, risking fatality. We describe a patient with BE, in whom antibiotic treatment alone resulted in complete recovery. On reviewing the literature, we found 12 additional such cases. We compared this group of I3 patients with data from 49 published cases treated with a combination of surgery and antibiotics, with afavorable outcome. Absence of congestive heart failure or a prosthetic valve, relatively mild extravalvular cardiac involvement, and a somewhat shorter disease history until initiation of treatment were characteristic of the group treated conservatively in comparison with patients who underwent surgery. In selected patients with BE, conservative antibiotic treatment may be a valid alternative to surgery.

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Prosthetic Valve Endocarditis Caused by Brucella melitensis

Cited by 27 publications

References 15 publications

Title Page: Brucella Endocarditis: From Non-Endemic Area: A Case Report.

Title Page: Brucella Endocarditis: From Non-Endemic Area: A Case Report.

Brucellosis in Patients with Heart Disease: When Should Endocarditis Be Diagnosed?

Conservative treatment for brucella endocarditis

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