Prosthetic replacement of esophageal segments

LaGuerre, Joseph N.; Schoenfeld, H; Calem, William S.; Gould, Francis E.; Levowitz, Bernard S.

doi:10.1016/s0022-5223(19)42794-3

Cited by 16 publications

(2 citation statements)

References 6 publications

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“…Attempts to preserve the continuity of the esophagus consisted primarily of procedures involving esophagocolostomy and esophagogastrostomy, 7 although experimentation with plastic 8 and synthetic constructs followed shortly after. 9,10 During the second half of the 20th century, esophageal replacement with different portions of the gastric tube [11][12][13][14][15][16][17] became the preferred treatment option, while experimentation with other alternatives such as aortic homografts 18 and prosthetic constructs 10,19,20 continued.…”

Section: Need For Esophageal Repairmentioning

confidence: 99%

Regenerative Medicine Strategies for Esophageal Repair

Londoño

Badylak

2015

Tissue Engineering Part B: Reviews

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Pathologies that involve the structure and/or function of the esophagus can be life-threatening. The esophagus is a complex organ comprising nonredundant tissue that does not have the ability to regenerate. Currently available interventions for esophageal pathology have limited success and are typically associated with significant morbidity. Hence, there is currently an unmet clinical need for effective methods of esophageal repair. The present article presents a review of esophageal disease along with the anatomic and functional consequences of each pathologic process, the shortcomings associated with currently available therapies, and the latest advancements in the field of regenerative medicine with respect to strategies for esophageal repair from benchtop to bedside.

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Section: Need For Esophageal Repairmentioning

confidence: 99%

Regenerative Medicine Strategies for Esophageal Repair

Londoño

Badylak

2015

Tissue Engineering Part B: Reviews

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“…Bei den Kunststoffprothesen bleibt als offenes Pro blem der gewebliche Einbau in den Wirts organismus (5,13). Hier verspricht jedoch die kürzlich entwickelte Prothese aus Gel-Kolla gen einen gewissen Fortschritt (10,12…”

Section: Postoperative Behandlungunclassified

Plastik der Speiseröhre mit Hilfe einer »heparinisierten« Dünndarmschlinge im Tierexperiment

Králík¹,

Korhon²,

Skibbe³

1971

Thorac cardiovasc Surg

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Comparative experimental study of esophageal wall regeneration after prosthetic replacement

Freud

Efrati

Kidron

et al. 1999

J. Biomed. Mater. Res.

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This study compares three prosthetic materials for potential use in patching and bridging congenital and acquired esophageal defects. The study was divided into two parts. In the first part, full-thickness, 6-cm2 cervical esophageal defects were induced in three groups of young mongrel dogs and were replaced with patches of lyophilized dura mater (Lyodura), polyethylene terephthalate (Dacron), or expanded polytetrafluoroethylene (PTFE). The dogs in the Lyodura subgroup were scheduled to be sacrificed after 1, 2, 4, 8, and 12 weeks and the dogs in the PTFE and Dacron subgroups were sacrificed after 1, 2, 3, 4, 6, and 7 months. The patched esophagus was removed for gross and microscopic examination. In the second part of the study a segment of the esophagus was excised in another three groups of dogs and replaced with 3 x 2 cm tubes of Lyodura, Dacron, or PTFE. Here the follow-up was prolonged and included radiological, endoscopic, and histological assessment. The dogs of each subgroup were scheduled to be sacrificed after 6, 8, and 12 months. Results indicated that lyophilized dura mater covered and neoepithelialized the patched area within the shortest period of time without foreign body reaction and with only slight collagen deposit, resulting in a ductile repaired esophageal wall. Therefore, its use may be considered for replacement of partial esophageal defects. For complete circumferential defects, the present study and our review of the literature showed that there is as yet no ideal prosthetic material that promotes good incorporation but is not prone to stenosis. Further studies in this area are required.

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Prosthetic replacement of esophageal segments

Cited by 16 publications

References 6 publications

Regenerative Medicine Strategies for Esophageal Repair

Regenerative Medicine Strategies for Esophageal Repair

Plastik der Speiseröhre mit Hilfe einer »heparinisierten« Dünndarmschlinge im Tierexperiment

Comparative experimental study of esophageal wall regeneration after prosthetic replacement

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