Prosthetic knee Candida parapsilosis infection

Microbiological, Clinical, and Surgical Features of Fungal Prosthetic Joint Infections: A Multi-Institutional Experience

“…Candida albicans was the causative organism in twentyone of forty-six cases 11,13,14,19,20,[23][24][25]27,28,31,34 . Candida parapsilosis was the second leading cause of fungal periprosthetic joint infection and was isolated in eleven cases 10,12,15,18,26,30,[35][36][37]39,40 , Candida glabrata was isolated from five cases 7,16,17,29,32,33 , and Candida tropicalis from five cases 13,17,21,38 . Rhodotorula minuta was reported as the cause of a periprosthetic infection in one case report 41 .…”

“…In other studies 24,30 , the diagnosis of candidal prosthetic infection has been confirmed with direct histologic evidence of fungi in retrieved osseous specimens. Several investigators 10,32,33,36 have stressed the importance of repeating fluid cultures and obtaining multiple positive tissue cultures before a diagnosis of fungal periprosthetic joint infection is made.…”

“…Wada et al 36 successfully treated a Candida parapsilosis infection of the knee with débridement and a regimen of oral fluconazole sodium (400 mg/day) for six months. Only a few other reports 10,15,34 have shown successful treatment of fungal periprosthetic joint infection with dé-bridement alone, which suggests that resection arthroplasty, Number of fungal periprosthetic infections reported so far according to our literature search.…”

Successful Two Stage Revision for Prosthetic Joint Infection Due to Candida albicans : Case Report

“…The authors noted efusion in their patient's knee only 2 weeks after surgery and on the 4 th postoperative week cultures were positive for Candida parapsilosis. 14 Levine et al reported successful results for Amphotericin B in eradication of Candida albicans. 4 However, use of systemic Amphotericin B has important side-effects such as nephrotoxicity and some patients may have difficulty in tolerating the drug, as it was in our case.…”

Fungal Biofilms in Human Disease

“…Indwelling catheters in the neonates patient group are an important risk factor for this organism (Pammi et al 2013 ). However, prosthetic knees, hip joints and breast implants have also been implicated (Wada et al 1998 ;Fox and Lee 2012 ;Younkin et al 1984 ), in addition to a substantial literature on its role on endocarditis of bioprosthetic valves (Wallner et al 2012 ;Garzoni et al 2007 ). C. tropicalis has also received attention in relation to biofi lm formation in vitro and in vivo, having been shown to be important in bioprosthetic heart valves and catheter related disease (Mansur et al 1996 ;Negri et al 2012 ).…”