Prosthetic hip infection due to Cryptococcus neoformans: case report

Johannsson, Birgir; Callaghan, John J.

doi:10.1016/j.diagmicrobio.2009.01.005

Cited by 40 publications

(23 citation statements)

References 14 publications

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“…Cryptococcus neoformans has been shown to colonize and subsequently form biofilms on ventricular shunts [15], peritoneal dialysis fistulas [16], prosthetic hip joints [17], and cardiac valves [18]. Different Trichosporon species can cause disseminated life-threatening infections associated with biofilm-related infections [14, 19, 20], including cardiac grafts [21], catheters [22], and breast implants [23].…”

Section: Clinical Significance Of Fungal Biofilmsmentioning

confidence: 99%

Fungal Biofilm Resistance

Ramage

Rajendran

Sherry

et al. 2012

International Journal of Microbiology

444

402

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Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required. This places a large financial burden on health care providers. This paper aims to illustrate the importance of fungal biofilms, particularlyCandida albicans, and discusses some of the key fungal biofilm resistance mechanisms that include, extracellular matrix (ECM), efflux pump activity, persisters, cell density, overexpression of drug targets, stress responses, and the general physiology of the cell. The paper demonstrates the multifaceted nature of fungal biofilm resistance, which encompasses some of the newest data and ideas in the field.

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Section: Clinical Significance Of Fungal Biofilmsmentioning

confidence: 99%

Fungal Biofilm Resistance

Ramage

Rajendran

Sherry

et al. 2012

International Journal of Microbiology

444

402

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show abstract

“…Less evidence is available for the treatment of infected hip joints, though it has been reported that voriconazole and amphotericin B have been used together in bone cement to treat a C. albicans infected hip (Deelstra et al 2013 ). Amphotericin B and fl uconazole have also been used to treat a C. neoformans infection of a prosthetic hip joint, but this was unsuccessful due to poor penetration through the biofi lm (Johannsson and Callaghan 2009 ). There are suggestions however that fluconazole may have a role in the treatment of candidal prosthetic joint infection (Kelesidis and Tsiodras 2010 ).…”

Section: Conventional Antifungal Approachesmentioning

confidence: 98%

Fungal Biofilms in Human Disease

Williams

Ramage

2014

Advances in Experimental Medicine and Biology

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“…The majority of fungal prosthetic joint infections are due to Candida species however, other fungal species have been reported including Aspergillus species, Cryptococcus neoformans, Zygomycetes, Histoplasma capsulatum, Rhodotorula minuta [75][76][77][78] (figure 4).…”

Section: Fungimentioning

confidence: 99%