Prostatitis Caused by Hansenula fabianii

Dooley, David P.; Beckius, Miriam L.; McAllister, C. Kenneth; Jeffery, Betty S.

doi:10.1093/infdis/161.5.1040

Cited by 19 publications

(20 citation statements)

References 5 publications

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“…We performed a PubMed search of cases through December 2007 using both Candida fabianii and Pichia fabianii as search terms and found only three cases in which this yeast species was reported to cause human infection, with none of them involving endocarditis. The first case, published by Dooley et al in 1990, was prostatitis in a 57-year-old male with chronic lymphocytic leukemia and a 20-year history of urinary tract infections [11]. He had multiple relapses on ketoconazole, but responded to amphotericin B.…”

Section: Discussionmentioning

confidence: 99%

A case of endocarditis caused by the yeastPichia fabianiiwith biofilm production and developedin vitroresistance to azoles in the course of antifungal treatment

et al. 2008

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Pichia fabianii, a yeast rarely causing human infections, was isolated from the blood of a patient with aortic valve endocarditis. The isolates were initially identified biochemically as Candida pelliculosa, but based on direct sequencing of the ITS2 region of rRNA, they were subsequently reidentified as P. fabianii. Antifungal therapy with fluconazole and later with voriconazole led to the development of resistant variants which had high MIC values to both antifungals. Strong biofilm formation by this yeast could also have played a role in the development of its resistance and allowed for its persistence on the infected valve during antifungal therapy. To our knowledge, this is the first published case of endocarditis and the fourth human infection caused by this yeast species.

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Section: Discussionmentioning

confidence: 99%

A case of endocarditis caused by the yeastPichia fabianiiwith biofilm production and developedin vitroresistance to azoles in the course of antifungal treatment

et al. 2008

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“…It may also be misidentified or be non-identifiable with phenotypic characteristics [8]. To our knowledge, there is only a single case report of an infection in the literature [9]. The patient was a 57-year-old male with chronic lymphocytic leukemia, schizophrenia, and a 20 year history of urinary tract infections and episodes of prostatitis due to an anatomic urogenital defect.…”

Section: Discussionmentioning

confidence: 99%

Infection in a neonate caused byPichia fabianii: Importance of molecular identification

et al. 2006

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Pichiafabianii, an uncommon yeast species recovered from clinical specimens, was documented as the cause of an infection in a 5-week-old female twin delivered at 25 and 3/7 weeks. She developed respiratory distress syndrome and necrotizing enterocolitis. At the time of the infection, she was febrile, thrombocytopenic, and still was requiring minimal ventilatory support. Blood cultures drawn on two consecutive days were positive for a germ tube negative yeast. Phenotypic methods including carbohydrate fermentations and assimilations (API 20C AUX) did not identify the yeast. Sequencing of D1/D2 domain of the large subunit rDNA was performed in one laboratory and sequencing a subunit of D2 performed in a second laboratory identified the yeast as P. fabianii. The organism was susceptible in vitro to amphotericin B, fluconazole and 5-fluorocytosinc. The patient responded to amphotericin B and removal of her vascular catheter. This case illustrates that there are an increasing number of fungi that may be pathogenic. Phenotypic tests may fail to identify them, emphasizing the need for commercially available, molecular based assays for identification.

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“…Results from a recent phylogenetic analysis based on large and small subunit ribosomal ribonucleic acids (rRNA) and translation elongation factor-1 α gene led to separation of the genus Cyberlindnera from its parental genus Williopsis [ 7 ]. Only 14 infections due to this organism have been reported [ 8 – 16 ]. Of the 14 cases, 10 involved fungemia [ 9 – 16 ] and 4 were limited to the genitourinary tract [ 8 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

First Report of Ventriculoperitoneal Shunt Infection due toCyberlindnera fabianii

Baghdadi

Hemarajata

Humphries

et al. 2015

Case Reports in Infectious Diseases

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Fungal infections in the central nervous system (CNS) are associated with significant morbidity and death. Transient fungemia in immunocompetent patients without any other risk factors for fungemia has been suggested as a possible mechanism that may lead to serious fungal ventriculoperitoneal (VP) shunt infections, but evidence is lacking. The clinical spectrum, diagnosis, and optimal therapy of Cyberlindnera fabianii infections remain to be determined. We describe the first case of CNS infection due to C. fabianii that occurred in an immunocompetent adult with a VP shunt. Spontaneous translocation with yeast that is not part of the normal gastrointestinal flora in the setting of ingestion of multiple servings of a fermentation product was the likely source from which Cyberlindnera fabianii gained entrance into the VP shunt system, causing meningitis in this patient. The authors conclude that, in view of the high morbidity associated with yeast infection of the CNS, long-term antifungal therapy should be strongly considered in cases where the VP shunt cannot be completely removed. Transient fungemia may lead to invasive disease in an immunocompetent host with VP shunt, even in the absence of any other risk factors for fungemia and even after remote placement of the VP shunt.

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Prostatitis Caused by Hansenula fabianii

Cited by 19 publications

References 5 publications

A case of endocarditis caused by the yeastPichia fabianiiwith biofilm production and developedin vitroresistance to azoles in the course of antifungal treatment

A case of endocarditis caused by the yeastPichia fabianiiwith biofilm production and developedin vitroresistance to azoles in the course of antifungal treatment

Infection in a neonate caused byPichia fabianii: Importance of molecular identification

First Report of Ventriculoperitoneal Shunt Infection due toCyberlindnera fabianii

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