Prostatic signet-ring adenocarcinoma: A case report

Abstract

Background: Prostatic signet-ring adenocarcinoma is a rare histological variant of prostate cancer. The tumor is characterized by an aggressive clinical course. Methods: Herein we present the case of a 78-year-old man with obstructive urinary symptoms and elevated serum prostate specific antigen. Transurethral resection of the prostate was performed. Results: Histologically, a tumor that was mainly composed of signet ring cells was identified. The tumor cells were positive for alcian blue special stain. Another Gleason 4 adenocarcinoma component was identified. The patient received hormonal therapy. A favorable response was documented at 8 months of follow up. Conclusions: Ruling out another primary site of origin, such as the gastrointestinal tract, is mandatory, and a more aggressive management plan should be put in mind.

Complementary Elements to the Pathogenesis, Early Detection and Second Line Antihormonal Therapy of Prostate Cancer

“…The case reports present atypical histologic cancer types. Al Khader A et al [9] present a signet-ring adenocarcinoma from Jordan, Kránitz N et al [10] two neuroendocrine cancers from Hungary. The cases illustrate the importance of the right diagnosis for the achievement of the best treatment outcomes.…”