Prostatic sarcoma after treatment of rectal cancer

Abbas, Saleh; Hill, Andrew G.

doi:10.1186/1477-7819-5-82

Cited by 6 publications

(6 citation statements)

References 24 publications

(22 reference statements)

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“…Adjuvant radiation is commonly utilized for advanced rectal adenocarcinoma after surgical resection, however the occurrence of radiation associated sarcoma after colorectal primary malignancy has been infrequently reported . A search of literature from 1947 to the present revealed only 3 prior cases (Table ).…”

Section: Discussionmentioning

confidence: 99%

Radiation‐associated sarcoma after recurrent colorectal primary tumor: A complex surgical case

Stephen

Fallon

Kalife

et al. 2015

Journal of Surgical Oncology

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Radiation associated sarcoma is a significant consequence of cancer therapy. Incidence of radiation associated sarcoma correlates with overall radiotherapy exposure. Prognosis is generally poor with 5 year survival rates lower than that for spontaneously occurring sarcomas. Surgical management presents many challenges including having to work in irradiated tissue planes while trying to achieve negative margins. We present a patient with a rare radiation associated pelvic sarcoma whose course illustrates the complexity of this problem.

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Section: Discussionmentioning

confidence: 99%

Radiation‐associated sarcoma after recurrent colorectal primary tumor: A complex surgical case

Stephen

Fallon

Kalife

et al. 2015

Journal of Surgical Oncology

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“…Саркома предстательной железы представляет собой крайне редкое заболевание, составляющее менее 1 % всех новообразований данной локализации [13]. По некоторым данным, средний возраст пациентов с саркомой предстательной железы варьирует от 30 до 40 лет, что гораздо меньше, чем для «классической» ацинарной аденокарциномы [14].…”

Section: обсуждение и обзор данных литературыunclassified

Undifferentiated pleomorphic prostate sarcoma: a rare clinical case and systematic literature review

Sorokin,

Dzitiev,

Kadrev

et al. 2024

Onkourologiâ

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Undifferentiated pleomorphic prostate sarcoma is an extremely rare neoplasm. In the available literature, less than 50 clinical cases were described. Usually, the clinical manifestation of the disease is nonspecific and is primarily associated with bladder outlet obstruction. Additionally, most patients have normal levels of prostate-specific antigen, while ultrasound and MRI can visualize irregularly shaped lesions, often extending beyond the prostate gland. Diagnosis requires exclusion of other signs of specific differentiation, apart from fibroblastic and myofibroblastic. There is no established treatment plan for patients with pleomorphic prostate sarcoma due to extreme rarity of the disease. For localized forms of the disease, radical laparoscopic prostatectomy is often used, but more aggressive treatment options are also being considered, including total pelvic exenteration, chemotherapy and radiation therapy. However, in most cases metastasis is revealed after primary treatment. Regional metastases are often localized in the rectum, bladder, in the area of previous surgery, and regional lymph nodes, while distant metastases are found in the lungs, liver, bones and distant lymph nodes, thereby indicating aggressive progression and poor prognosis of the disease.In this article, we present our own clinical observation of a patient with confirmed undifferentiated pleomorphic prostate sarcoma.

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“…NICE guidance also recommends that men treated with radical radiotherapy for prostate cancer should be offered flexible sigmoidoscopy every five years 25 . However, radiotherapy may also increase the rate of other cancers such as sarcomas, which are not necessarily mucosal in origin and may be missed by flexible sigmoidoscopy 52 . After pelvic radiotherapy, even if five-yearly follow-up surveillance of the rectal mucosa is planned, there should be a low threshold for investigation of rectal bleeding to avoid missing interval cancers as it cannot be assumed that the usual polyp-cancer sequence occurs with radiation induced cancers.…”

Section: Longer Term Effects Of Radiotherapy and Patient Follow-upmentioning

confidence: 99%

Interactions in the aetiology, presentation and management of synchronous and metachronous adenocarcinoma of the prostate and rectum

Nash

Turner

Hickish

et al. 2012

annals

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Adenocarcinoma of the prostate and rectum are common male pelvic cancers and may present synchronously or metachronously and, due to their anatomic proximity. The treatment of rectal or prostate cancer (in particular surgery and/or radiotherapy) may alter the presentation, incidence and management should a metachronous tumour develop. This review focuses on the interaction between prostatic and rectal cancer diagnosis and management. We have restricted the scope of this large topic to general considerations, management of rectal cancer after prostate cancer treatment and vice versa, management of synchronous disease and cancer follow-up issues.

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Prostatic sarcoma after treatment of rectal cancer

Abstract: Background: The relationship between radiation exposure for treatment of cancer and occurrence of a second primary cancer at the irradiated site is well known. This phenomenon is however rare in prostate.

Cited by 6 publications

References 24 publications

Radiation‐associated sarcoma after recurrent colorectal primary tumor: A complex surgical case

Radiation‐associated sarcoma after recurrent colorectal primary tumor: A complex surgical case

Undifferentiated pleomorphic prostate sarcoma: a rare clinical case and systematic literature review

Interactions in the aetiology, presentation and management of synchronous and metachronous adenocarcinoma of the prostate and rectum

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