Prostatic length predicts functional outcomes after iodine-125 prostate brachytherapy

Pal, Rekha; Bhatt, Jaimin R.; Khan, Masood A.; Duggleby, S.; Camilleri, Philip; Bell, C. Richard; Elwell, Christine; Kunkler, R.

doi:10.1016/j.brachy.2010.06.010

Cited by 11 publications

(3 citation statements)

References 31 publications

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“…High-dose-rate brachytherapy has the technical advantage of control over post-implant dosimetry, although it is much more invasive than LDR brachytherapy [ 18 ]. While there is some evidence to suggest that prostate length is associated with late GU toxicity likely due to greater medial lobe size and correspondingly higher doses to the bladder neck, presumably due to backscatter from the medial lobe to the bladder neck, our data did not demonstrate such a relationship [ 19 – 21 ].…”

Section: Discussioncontrasting

confidence: 75%

Influence of zonal dosimetry on prostate brachytherapy outcomes

Hong¹,

Reddy²,

Wilkinson³

et al. 2015

jcb

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PurposeTo examine the influence of zone-specific dosimetry on outcomes during permanent prostate implantation (PI), where the peripheral zone (PZ) and transitional zone (TZ) may receive varying radiation doses.Material and methodsFour hundred and sixteen patients treated with I-125 PI (target dose: 144 Gy) between 1996 and 2003 were included in this Institutional Review Board (IRB) approved, retrospective analysis. Whole prostate (WP), TZ, and PZ were contoured, and zone-specific D90 and V100 were computed. Their influence on biochemical failure (BF) was evaluated using Cox proportional hazards analysis.ResultsThe median age and initial prostate-specific antigen (PSA) was 68 years and 6.1 ng/ml, respectively, and the median follow-up time was 8.8 years. There were 329 subjects with Gleason score (GS) 6 disease (79.1%), and 82 subjects had GS 7 disease (19.7%). Androgen deprivation therapy (ADT) was used in 20.4% of patients. Median D90 and V100% in the WP, PZ, and TZ were 141.2 Gy, 156.1 Gy, and 134.5 Gy; and 88.8%, 93.3%, and 84.2%, respectively. Ten-year rates for biochemical recurrence-free survival, distant metastasis-free survival, and prostate cancer-specific mortality were 82.4%, 92.4%, and 0.97% respectively. Only initial PSA, GS7+ disease, ADT, and PSA frequency were significant on multivariate analysis. Ten-year rates of grade 3 or higher GU and GI toxicity was 10.9% and 1.8%, respectively. TZ V200 and TZ V300 were significantly associated with late genitourinary toxicity.ConclusionsThe TZ received significantly lower doses of radiation compared to the PZ. On multivariate analysis, no dosimetric parameter was associated with efficacy. Higher TZ doses may be associated with higher late GU toxicity without improving efficacy.

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Section: Discussioncontrasting

confidence: 75%

Influence of zonal dosimetry on prostate brachytherapy outcomes

Hong¹,

Reddy²,

Wilkinson³

et al. 2015

jcb

View full text Add to dashboard Cite

show abstract

“…Highdose-rate brachytherapy has the technical advantage of control over post-implant dosimetry, although it is much more invasive than LDR brachytherapy [18]. While there is some evidence to suggest that prostate length is associated with late GU toxicity likely due to greater medial lobe size and correspondingly higher doses to the bladder neck, presumably due to backscatter from the medial lobe to the bladder neck, our data did not demonstrate such a relationship [19][20][21].…”

Section: Discussioncontrasting

confidence: 73%

Influence of Zonal Dosimetry on Prostate Brachytherapy Outcomes

Hong

Reddy

Wilkinson

et al. 2014

International Journal of Radiation Oncology*Biology*Physics

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“…The preoperative characteristics of the patients included in each group can be compared with those of the series so far published (9-13, 17-18). In our series, we found differences regarding mean age which can be explained by a tendency of ageing patients to choose BT to avoid the anesthetic complications of surgery.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of short - term functional outcomes and quality of life in a prospective series of brachytherapy and Da Vinci robotic prostatectomy

et al. 2017

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Introduction There is a growing interest in achieving higher survival rates with the lowest morbidity in localized prostate cancer (PC) treatment. Consequently, minimally invasive techniques such as low-dose rate brachytherapy (BT) and robotic-assisted prostatectomy (RALP) have been developed and improved. Comparative analysis of functional outcomes and quality of life in a prospective series of 51BT and 42Da Vinci prostatectomies DVMaterials and Methods Comparative analysis of functional outcomes and quality of life in a prospective series of 93 patients with low-risk localized PC diagnosed in 2011. 51patients underwent low-dose rate BT and the other 42 patients RALP. IIEF to assess erectile function, ICIQ to evaluate continence and SF36 test to quality of life wee employed.Results ICIQ at the first revision shows significant differences which favour the BT group, 79% present with continence or mild incontinence, whereas in the DV group 45% show these positive results. Differences disappear after 6 months, with 45 patients (89%) presenting with continence or mild incontinence in the BT group vs. 30 (71%) in the DV group. 65% of patients are potent in the first revision following BT and 39% following DV. Such differences are not significant and cannot be observed after 6 months. No significant differences were found in the comparative analysis of quality of life.Conclusions ICIQ after surgery shows significant differences in favour of BT, which disappear after 6 months. Both procedures have a serious impact on erectile function, being even greater in the DV group. Differences between groups disappear after 6 months.

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Prostatic length predicts functional outcomes after iodine-125 prostate brachytherapy

Cited by 11 publications

References 31 publications

Influence of zonal dosimetry on prostate brachytherapy outcomes

Influence of zonal dosimetry on prostate brachytherapy outcomes

Influence of Zonal Dosimetry on Prostate Brachytherapy Outcomes

Comparative analysis of short - term functional outcomes and quality of life in a prospective series of brachytherapy and Da Vinci robotic prostatectomy

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