Prostatic involvement by transitional cell carcinoma in patients with bladder cancer and its prognostic significance

Shen, Steven S.; Lerner, Seth P.; Müezzínoğlu, Bahar; Truong, Luan D.; Amiel, Gilad E.; Wheeler, Thomas M.

doi:10.1016/j.humpath.2006.01.027

Cited by 105 publications

(78 citation statements)

References 20 publications

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“…These results highlight the importance of a carefully description of UPI in prostate specimens after radical cystoprostatectomy. We confirm that whole mount sections detected higher incidence of UPI as previously described [27,28].…”

Section: Discussionsupporting

confidence: 91%

Impact of the level of urothelial carcinoma involvement of the prostate on survival after radical cystectomy

Moschini¹,

Soria²,

Martin³

et al. 2016

European Urology Supplements

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Abstract.Objective: Urothelial prostatic involvement (UPI) at the time of radical cystoprostatectomy (RCP) was found associated with worse survival outcomes by several previous reports. Our aim is to evaluate the impact of different levels of UPI on survival outcomes using a large series of male patients treated with RCP. Methods: Whole step section specimens from 995 male BCa patients were assessed for UPI defined as: no involvement vs. prostatic urethral carcinoma in situ (CIS) vs. lamina propria involvement vs. ductal CIS vs. prostate stromal involvement. Primary end point of the study was predictors of prostatic involvement at RCP and its impact on overall survival after surgery. Results: Prostatic involvement was recorded in 307 (30.9%) patients: 28% with prostatic urethral CIS, 12% with lamina propria involvement, 13% with ductal CIS and 47% with stromal involvement. Median follow-up was 70 months. Patients with stromal involvement had a worse 5-year survival (12%) than those with prostatic urethra CIS (40%), lamina propria involvement (36%), and ductal CIS (35%). Considering predictors of prostatic involvement, multifocal tumor (Odds Ratio [OR]: 6.60, p < 0.001), lymphovascular invasion (OR: 2.61, p < 0.001), lymph node metastases (OR: 2.02, p < 0.001) and CIS (OR: 2.02, p < 0.001) were found associated. Similar predictors were found assessing stromal involvement. 162 M. Moschini et al. / Urothelial Prostatic Involvement during Radical CystectomyConclusions: Approximately one third of RCP patients harbor prostatic involvement of urothelial carcinoma. While all UPI are associated with worse overall survival, stromal involvement confers the worst outcome supporting its classification as T4 in the TNM staging.

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Section: Discussionsupporting

confidence: 91%

Impact of the level of urothelial carcinoma involvement of the prostate on survival after radical cystectomy

Moschini¹,

Soria²,

Martin³

et al. 2016

European Urology Supplements

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show abstract

“…In the remaining 74% of cases, the prostate was invaded by urothelial carcinoma extending from the prostatic urethra. 95 More recently, Montironi et al 96 reported a detailed histopathological analysis of 248 consecutive prostates from cystoprostatectomies for muscle-invasive bladder carcinoma, using the whole mount technique. Involvement by bladder cancer was present in 38% of the prostates.…”

Section: Stage Pt4 Carcinomamentioning

confidence: 99%

Staging and reporting of urothelial carcinoma of the urinary bladder

et al. 2009

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“…Ürotelyal karsinom: Nadir olmakla birlikte prostatın ürotelyal epitelle döşeli büyük, santral kanallarında primer tümör olarak ortaya çıkabilmektedir [44,45]. Trombomodulin, GATA3, p63 ve yüksek molekül ağırlıklı sitokeratin eksprese ederler.…”

Section: Duktal Adenokarsinomunclassified

“…Buna karşın PSA, PSAP, NKX3.1 ve prostein negatiftirler. Prognozları patolojik evre ile ilişkilidir [44,45].…”

Section: Duktal Adenokarsinomunclassified

Prostat Kanser Patolojisi

Baydar¹,

Fakultesi²

2018

Trd Sem

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Prostatic involvement by transitional cell carcinoma in patients with bladder cancer and its prognostic significance

Cited by 105 publications

References 20 publications

Impact of the level of urothelial carcinoma involvement of the prostate on survival after radical cystectomy

Impact of the level of urothelial carcinoma involvement of the prostate on survival after radical cystectomy

Staging and reporting of urothelial carcinoma of the urinary bladder

Prostat Kanser Patolojisi

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