Prostatic epithelium inhibiting factor (PEIF): Organ specificity and production by prostatic fibroblasts

Jj, König; Jc, Romijn; Fh, Schröder

doi:10.1007/bf00254426

Cited by 23 publications

(12 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vitro coculture studies have produced conflicting results of cell regulation. Primary stromal cells were growth stimulatory to normal and malignant epithelial cells (Kabalin et al 1989, Gleave et al 1991, yet in other studies the stromal cells were inhibitory to epithelial growth (König et al 1987, Kooitsra et al 1995, Degeorges et al 1996. Cell culture models of AR function in normal primary prostate epithelial cells have been limited.…”

Section: Cell Culture Models To Understand Ar Function and Cell Commumentioning

confidence: 99%

Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell's fault.

Arnold¹,

Isaacs²

2002

Endocrine-Related Cancer

184

135

View full text Add to dashboard Cite

The acquisition of an androgen-independent phenotype by prostate cancer cells is presently a death sentence for patients. In order to have a realistic chance of changing this outcome, an understanding of what drives the progression to androgen independence is critical. We review here a working hypothesis based on the position that the development of androgen-independent epithelial cells is the result of a series of cellular and molecular events within the whole tissue that culminates in the loss of normal tissue-maintained growth control. This tissue includes the epithelial and stromal cells, the supporting extracellular matrix and circulating hormones. This review discusses the characteristics of these malignant cells, the role of stromal cells involved in growth and the differentiation of epithelial cells, and the role of the extracellular matrix as a mediator of the phenotypes of stromal and epithelial cells. In addition, environmental, neuroendocrine and immune factors that may contribute to disturbance of the fine balance of the epithelial-stromal-extracellular matrix connection are considered. While the goal of many therapeutic approaches to prostate cancer has been androgen ablation or targeting the androgen receptor (AR) of epithelial cells, these therapies become ineffective as the cells progress beyond dependence on androgen for growth control. Twenty years ago Sir David Smithers debated that cancer is the result of loss of tolerance within tissues and the organizational failure of normal growth-control mechanisms. This is precipitated by prolonged or abnormal demands for regeneration or repair, rather than of any inherent disorder peculiar to each of the individual components involved. He wrote 'It is not the cell itself that is disorderly, but its relationship with the rest of the tissue'. We have gained significantly large amounts of precise data on the effects of androgenic ablation on cancerous prostate cells and on the role of the AR in prostate cancer. The need has come to compile this information towards a perspective of dysregulation of tissue as a whole, and to develop experimental systems to address this broader perspective to find and develop therapies for treatment and prevention.

show abstract

Section: Cell Culture Models To Understand Ar Function and Cell Commumentioning

confidence: 99%

Mechanisms involved in the progression of androgen-independent prostate cancers: it is not only the cancer cell's fault.

Arnold¹,

Isaacs²

2002

Endocrine-Related Cancer

184

135

View full text Add to dashboard Cite

show abstract

“…63 Later, monolayer cultures were specifically used to investigate prostatic epithelial cell characteristics and function. 64,65 In more recent times, human cultured prostatic stromal cells have gained credence in the investigation of prostatic stromal contractility, [66][67][68] second messenger pathway activity, 67,69,70 proliferation 71,72 and apoptosis. 73,74 Given the abundance of studies showing biological effects in both whole tissue and cultured cells, it seems appropriate to address the obvious question of how suitable cultured stromal cells are as a model of intact prostatic tissue.…”

Section: Cultured Cell Models Of Human Prostate Contractilitymentioning

confidence: 99%

Current models of human prostate contractility

Haynes

Ventura

2005

Clin Exp Pharma Physio

View full text Add to dashboard Cite

SUMMARY1. The human prostate is a compact gland contributing to seminal fluid. With increasing age, most humans will develop benign prostatic hyperplasia, a condition of prostatic enlargement and contractility that leads to occlusion of the urethra. Over many years, investigators have used a variety of animal and cell culture models to elucidate some of the contractile and proliferative mechanisms that may be associated with the development of this condition.2. This review briefly assesses the current state of knowledge of the mechanisms underlying human prostatic contractility and compares it with that of animal and cell culture models. It is not intended as a comprehensive methodological review, nor is it intended to indicate our preferences for either model. Our aim is to correlate findings from animal and cell culture models with the current understanding of human prostate contractility.3. We hope that the present review will increase awareness of the suitability of the current models in developing our understanding of benign prostatic hyperplasia.

show abstract

“…In contrast, some investigators [17] have shown that tumor associated stromal cells inhibit epithelial cell growth by production of a specific inhibitory factor termed as prostatic epithelium inhibiting factor (PEIF). The expression of this factor by stromal cells was only in the conditioned media collected from isolated stromal cell subcultures.…”

Section: Stromal Cells In Prostate Carcinogenesismentioning

confidence: 98%