Prostatic embryonal rhabdomyosarcoma in adults. A clinicopathologic review

Waring, Paul; Newland, R. C.

doi:10.1002/1097-0142(19920201)69:3<755::aid-cncr2820690324>3.0.co;2-y

Cited by 63 publications

(59 citation statements)

References 40 publications

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“…19 There are o20 prostatic rhabdomyosarcomas that have been reported in adults ranging in age from 17 to 68 years old. 20,21 As in younger patients, embryonal subtype is the predominant pattern. In contrast to the relatively good prognosis for treated rhabdomyosarcoma in children, the prognosis in adults is poor with most dying of disease in o2 years, despite multimodality therapy.…”

Section: Rhabdomyosarcomamentioning

confidence: 99%

Spindle cell lesions of the adult prostate

et al. 2007

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Prostatic spindle cell lesions are diagnostically challenging and encompass a broad array of benign and malignant processes. A subset of these lesions arises only within the prostate and generally represents entities that originate from the prostate epithelium or stroma, such as sclerosing adenosis, sarcomatoid carcinoma, stromal tumors of uncertain malignant potential (STUMP), and stromal sarcoma. Another subset of spindle cell tumors that involve the prostate are also found at other sites and include solitary fibrous tumor, leiomyosarcoma, and neural lesions among others. Finally, tumors may secondarily involve the prostate yet present as primary prostatic processes, as is evident with several cases of gastrointestinal stromal tumors (GIST). The utility of ancillary studies, including immunohistochemistry, is often limited and the main criteria for diagnosis are the morphologic findings by routine H&E stain. This review addresses the various entities that may present as spindle cell tumors within the adult prostate and discusses the functional aspects of the differential diagnosis of these lesions.

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Section: Rhabdomyosarcomamentioning

confidence: 99%

Spindle cell lesions of the adult prostate

et al. 2007

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“…In this report, the 5-year event-free survival and 5-years overall survival were 32.9 months and 45.7 months respectively, suggesting the worse outcome of adults with RMS than children; however, subgroup analysis showed that genitourinary RMS were not associated with the worst reported outcomes. Other previous series of adults prostatic rhabdomyosarcoma have reported poor results and significantly different natural history of genitourinary tract tumors in these patients in comparison to children [14]- [16].…”

Section: Discussionmentioning

confidence: 91%

“…It is characterized by a high degree of malignancy, both local rapid growth with formation of large pelvic masses, often leading to renal failure due to urethral obstruction, and systemic spread, commonly to the lungs, liver bone and regional lymph nodes [3]. The histogenesis of embryonal rhabdomyosarcomas is curious because they have a propensity to arise in tissues, such as the middle ear, bile duct, bladder, and prostate, that are devoid of skeletal muscle.…”

Section: Discussionmentioning

confidence: 99%

Adult Primary Prostate Embryonal Rhabdomyosarcoma: Report of a Case and Revue of Literature

Amaadour¹,

Tahiri²,

Ameurtesse³

et al. 2014

JCT

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Introduction: Primary embryonal rhabdomyosarcoma of prostate (ERMP) is an extremely rare pathological and clinical entity in adults. It's characterized by extensive loco-regional spread and a tendency to metastasize by blood stream and regional lymphatics. In adult patients, data available on the management of ERMP are limited and mostly derived from the pediatric clinical trials on rhabdomyosarcoma. Case Report: We report a case of group III ERMP approached by initial surgery followed by the administration of three courses of vincristine, doxorubicin and Cyclophosphamide regimen. The patient succumbed to disease complications three months after the original diagnosis. Conclusion: The most appropriate therapeutic approach for adults with ERMP remains questionable. Further studies are needed to improve the understanding of biological behavior of ERMP in adults and to define the best therapeutic strategy in locally advanced disease.

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“…38 There is no doubt that rhabdomyosarcoma of the prostate is a tumor of children with a peak age of incidence of 5 years. 111 However, over 30 cases occurring in adults above the age of 18 years are on record, 112,118 with few of them seen in men over 60 years of age. 38,112,113 The overwhelming majority of pediatric cases are of the embryonal subtype, but in adults slightly over one-third of the reported cases were of this subtype.…”

Section: Rhabdomyosarcoma Of the Adult Prostatementioning

confidence: 99%

“…111 However, over 30 cases occurring in adults above the age of 18 years are on record, 112,118 with few of them seen in men over 60 years of age. 38,112,113 The overwhelming majority of pediatric cases are of the embryonal subtype, but in adults slightly over one-third of the reported cases were of this subtype. 38,112,113 Few cases were of the alveolar 38,119 or the pleomorphic 38 subtypes.…”

Section: Rhabdomyosarcoma Of the Adult Prostatementioning

confidence: 99%

Nonepithelial Tumors and Tumor-Like Lesions of the Prostate Gland

Shabaik

2003

Critical Reviews in Clinical Laboratory Sciences

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Many significant benign and malignant nonepithelial tumors and stromal tumor-like lesions arise in the prostate gland. Although such lesions are rare, their recognition by the pathologist is essential because their treatment and prognosis are quite variable. In this review, lesions of the specialized prostatic stroma, that is, lesions that can be seen in the stroma of the prostate but not in that of other organs, except for the phyllodes type of lesions, are discussed. Benign and malignant lesions of the soft tissues that occur in the stroma of other organs and are seen with some frequency in the prostate are also discussed. Few of the rarer soft tissue lesions are mentioned. Lesions and tumors with melanocytic differentiation, hematopoietic derivation, and germ cell tumors are described. It is hoped that this review will serve as a useful reference when encountering some of these lesions, all of which are referenced to their original and subsequent reports. Some non-English language references are also cited to reflect the international recognition of these lesions or to give credit to the author who first described the entity.

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Prostatic embryonal rhabdomyosarcoma in adults. A clinicopathologic review

Cited by 63 publications

References 40 publications

Spindle cell lesions of the adult prostate

Spindle cell lesions of the adult prostate

Adult Primary Prostate Embryonal Rhabdomyosarcoma: Report of a Case and Revue of Literature

Nonepithelial Tumors and Tumor-Like Lesions of the Prostate Gland

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