Prostatic aspirates a cytomorphologic analysis with emphasis on well‐differentiated carcinoma

Abstract

In this retrospective evaluation of 72 cases of fine needle aspiration biopsy of the prostate, 25 aspirates from well-differentiated carcinoma were compared with 27 aspirates from benign prostatic enlargement and 20 aspirates from moderately to poorly differentiated carcinoma. Each case was examined by a single observer (V.K.) for multiple parameters including cellularity, dyshesion, nuclear membrane irregularity, anisonucleosis, macronucleoli (major criteria of malignancy), cell and nuclear enlargement, and altered nuclear/cytoplasmic ratio. Cellularity was the most significant indicator, but all major and minor criteria of malignancy were consistently important for distinguishing well-differentiated carcinoma from benign lesions. Systematic use of these meaningful standards enhances diagnostic sensitivity.

Evaluation of The Role of Transrectal Fine Needle Aspiration As A Diagnostic Modality in The Diseases of Prostate with Review of Literature

“…Al-Ababi compared the results of cytology and histology and found that the sensitivity of fine needle aspiration was 98.0% as compared to core biopsy sensitivity of 96.0% in carcinoma prostate. 39 [5][6][7]25,[39][40][41][42][43][44][45][46][47] But our results were contradictory to the study of William and Ou et al 48,49 The evaluation of transrectal FNAC in prostatic carcinoma in our study showed a sensitivity of 88.8%, which is comparable to the findings by Saleh et al and Kaur et al, who have reported it to be 88.0% and 90% respectively. 47,50 Our study showed a positive predictive value of 100.0% in malignancy and 92.3% in benign prostatic hypertrophy on FNAC.…”

“…28,45 False negative diagnosis in our study 11.2% which was equivalent to Kline and Kannan and Ingle and Ingle, who reported 12.0% and 12.8% respectively. 7,10 Melagrana et al and Lin et al reported higher false negative cases as 20.0% and 29.0% respectively. 52,53 As most of the clinicians are aware of the hazards which is inherent, mostly on account of insufficient smears and are always prepared to repeat the aspiration, if they clinically suspect malignancy.…”

“…Klnie and Kannan in 1977 found excellent results of the Franzen technique. 7 India was sluggish in accepting this procedure, on account of reluctance on the part of general pathologists and lack of experience of the clinician and urologist. Hence very few reports are available from India till end of the 20 th century.…”

Architectural patterns in cytology: correlation with histology

“…Benign prostatic hyperplasia is just one example of this type of arrangement. [18][19][20] This arrangement also is very frequently seen in samples from impression smears or scrapings 21 and pinch biopsies of gastric or intestinal mucosa. 22 Acinar Acinar patterns are characteristic of glandular tissue, where the basic unit is a group of cells arranged around an empty or secretion-filled central area (Figures 2E-H).…”

Aspiration biopsy cytology of the prostate in young adult men

“…On the other hand, a combination of large and small groups is infrequent in BPE, and aspirates from such nodules are usually composed exclusively of cell groups of one size. 3 The findings in this autopsy series of benign FNABs from young men and the case report differ from the conventional criteria in that the smears were highly cellular with abundant small glandular groups present either exclusively or in combination with large groups, thus suggesting dyshesion. These features are noted readily at low or scanning power and can give an initial impression of possible malignancy.…”