Prostatic adenocarcinoma of ductal origin

Dube, Volkjer E.; Farrow, George M.; Greene, Laurence F.

doi:10.1002/1097-0142(197308)32:2<402::aid-cncr2820320218>3.0.co;2-q

Cited by 133 publications

(71 citation statements)

References 11 publications

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“…Type B shows cribriform patterned or solid growth with frequent comedonecrosis and marked nuclear atypia. Type A almost matches with adenocarcinoma of the primary prostatic ducts, and type B with adenocarcinoma of the secondary prostatic ducts, as reported by Dube et al [2] Cytological atypia of PDA is characteristically higher than that of conventional acinar carcinoma: irregular chromatin distribution, distinct nucleoli, and frequent mitotic figures. However, in some cases of type A, the cytological atypia is minimal as this case, and small biopsy specimens can hardly be diagnosed as a carcinoma [5].…”

supporting

confidence: 78%

“…Dube et al [2] reported that the 5-year survival rate was 42.8% for a PDA of primary duct origin (type A) and 24.2% for a PDA of secondary duct origin (type B), and the prognosis for type A is analogous to that for acinar adenocarcinoma. The rate for type B is significantly worse than that for type A; however, it is not clear if cytological atypia correlates with prognosis [5].…”

mentioning

confidence: 99%

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Prostatic ductal adenocarcinoma mimicking villous adenoma of the urethra

Sato

Tachibana

Tsuzuki³

et al. 2006

Virchows Arch

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supporting

confidence: 78%

mentioning

confidence: 99%

Prostatic ductal adenocarcinoma mimicking villous adenoma of the urethra

Sato

Tachibana

Tsuzuki³

et al. 2006

Virchows Arch

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“…DAP is considered an unusual form of prostatic adenocarcinoma accounting in its pure form for less than 1% of cases, and when admixed with usual acinar type carcinoma for about 5% of prostatic malignancies [3,[11][12][13]. In our study, based on an unselected consecutive series of patients who underwent radical prostatectomy, DAP in association with AA was found to be more common than previously reported, comprising 12.7% of tumors, although in its pure form, it involved only b1% of cases in our series.…”

Section: Discussionmentioning

confidence: 99%

“…The importance of a diagnosis of DAP and the value of differentiating these tumors from AA has been [3][4][5][6]13]. In contrast AA, including those showing cribriform and papillary morphology, is composed of predominantly cuboidal cells, whereas tall columnar cells with prominent atypia and frequent mitoses typical of DAP are not seen.…”

Section: Discussionmentioning

confidence: 99%

Any proportion of ductal adenocarcinoma in radical prostatectomy specimens predicts extraprostatic extension

Samaratunga¹,

Duffy²,

Yaxley³

et al. 2010

Human Pathology

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“…[1][2][3][4][5][6][7][8][9][10] Most studies have shown a more aggressive clinical course for ductal adenocarcinoma compared with usual acinar adenocarcinoma. [6][7][8][9][10][11][12][13][14] There has been debate as to whether ductal adenocarcinoma is an entity that is distinct from acinar adenocarcinoma. 1,5 Ductal adenocarcinomas are often admixed with acinar adenocarcinoma and ductal and acinar adenocarcinomas can share certain histopathological attributes such as cribriform growth and origin in the peripheral zone.…”

mentioning

confidence: 99%

Gene expression profiles of ductal versus acinar adenocarcinoma of the prostate

et al. 2009

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Ductal adenocarcinoma is an uncommon variant of prostatic adenocarcinoma with a generally more aggressive clinical course than usual acinar adenocarcinoma. However, the molecular distinction between ductal and acinar adenocarcinomas is not well characterized. The aim of this investigation was to evaluate the relatedness of ductal versus acinar prostatic adenocarcinoma by comparative gene expression profiling. Archived, deidentified, snap frozen tumor tissue from 5 ductal adenocarcinomas, 3 mixed ductal-acinar adenocarcinomas, and 11 acinar adenocarcinomas cases were analyzed. All cases of acinar and ductal adenocarcinomas were matched by Gleason grade. RNA from whole tissue sections of the 5 ductal and 11 acinar adenocarcinomas cases were subjected to gene expression profiling on Affymetrix U133Plus2 microarrays. Independently, lasercapture microdissection was also performed on the three mixed ductal-acinar cases and five pure acinar cases to isolate homogeneous populations of ductal and acinar carcinoma cells from the same tumor. Seven of these laser-capture microdissected samples (three ductal and four acinar cell populations) were similarly analyzed on U133Plus2 arrays. Analysis of data from whole sections of ductal and acinar carcinomas identified only 25 gene transcripts whose expression was significantly and at least two-fold different between ductal and acinar adenocarcinomas. A similar analysis of microdissected cell populations identified 10 transcripts, including the prolactin receptor, with more significant differences in expression of 5-to 27-fold between ductal and acinar adenocarcinomas cells. Overexpression of prolactin receptor protein in ductal versus acinar adenocarcinoma was confirmed by immunohistochemistry in an independent set of tumors. We conclude that ductal and acinar adenocarcinomas of the prostate are strikingly similar at the level of gene expression. However, several of the genes identified in this study, including the prolactin receptor, represent targets for further investigations on the molecular basis for histomorphological and clinical behavioral differences between acinar and ductal adenocarcinomas.

show abstract

Prostatic adenocarcinoma of ductal origin

Cited by 133 publications

References 11 publications

Prostatic ductal adenocarcinoma mimicking villous adenoma of the urethra

Prostatic ductal adenocarcinoma mimicking villous adenoma of the urethra

Any proportion of ductal adenocarcinoma in radical prostatectomy specimens predicts extraprostatic extension

Gene expression profiles of ductal versus acinar adenocarcinoma of the prostate

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