Prostate volume and age are predictors of energy delivery using the CoreTherm Concept in patients with LUTS/BPO: a study on thermal dose

Abstract

Objective: The primary aim of this study was to evaluate the scientific evidence supporting the use of thermal dose as a secondary (or an alternative) endpoint when using the CoreTherm Concept. Material and methods: Baseline and treatment data from 283 consecutive treatments were evaluated. All patients had lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH). After evaluation, benign prostatic enlargement (BPE) with benign prostatic obstruction (BPO) was evident. As treatment, the CoreTherm Concept was used in all patients with LUTS/BPO. Data parameters were retrospectively extracted and included patient age, prostate volume, energy delivery, treatment time and calculated cell kill. In addition, assessment of temperature curves and calculated intraprostatic blood flow was made to define an optimal treatment. In total, 199 treatments assessed as optimal were included in the study. Results: There was a significant correlation between pretreatment prostate volume and energy delivery (p < .001). Age also influenced energy consumption significantly (p ¼ .01). Conclusion:The solid correlation between pretreatment prostate volume and age versus total energy deposition implies the recommendation that a pretreatment calculation of an appropriate energy deposition should be used in all treatments as an alternative treatment endpoint.

Treatment with CoreTherm in 570 patients with prostate volumes of 80-366 ml: an evaluation of short- and long-term retreatment risk

“…Treatment data: treatment time, energy consumption and calculated cell kill were collected from the computer software. Application procedure of mepivacaine and adrenaline, pre-and postoperative medication and follow-up protocol are identical to what has been previously described from our group [3,10,12].…”

“…This modern treatment with CoreTherm is nowadays, after the introduction of the injection catheter two decades ago almost exclusively performed in conjunction with injections of mepivacaine and adrenaline. The calculated cell kill is based on a software algorithm and provides data on prostate tissue ablation in real time, thereby enabling tailoring of treatment [3,12].…”

“…CoreTherm is associated with few complications and is easy to learn, especially when using the alternative treatment endpoint [12]. Furthermore, treatment with CoreTherm is also a feasible option for patients with urinary retention [14,15], most often caused by BPO [13].…”