Prostate transmembrane androgen inducible protein 1 (PMEPA1): regulation and clinical implications
Qicui Zhu,
Yue Wang,
Yaqian Liu
et al.
Abstract:Prostate transmembrane androgen inducible protein 1 (PMEPA1) can promote or inhibit prostate cancer cell growth based on the cancer cell response to the androgen receptor (AR). Further, it can be upregulated by transforming growth factor (TGF), which downregulates transforming growth factor-β (TGF-β) signaling by interfering with R-Smad phosphorylation to facilitate TGF-β receptor degradation. Studies have indicated the increased expression of PMEPA1 in some solid tumors and its functioning as a regulator of m… Show more
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