Prostate T₁ quantification using a magnetization‐prepared spiral technique

Abstract

Purpose: To adapt a magnetization-prepared spiral imaging technique, termed T1prep, for time-efficient radiofrequency (RF)-insensitive prostate T 1 quantification at 1.5 T and evaluate signal-to-noise ratio (SNR) limits to voxelbased versus subregion analysis. Materials and Methods:A magnetization-prepared spiral imaging technique was adapted for robust T 1 contrast development, multislice imaging within 5 minutes, and data regression to a monoexponential decay. In vitro testing evaluated RF insensitivity of the multislice acquisition plus method accuracy. A pilot study was performed in 15 patients with low or intermediate risk localized prostate cancer.

MR elastography to measure the effects of cancer and pathology fixation on prostate biomechanics, and comparison withT1,T2and ADC

“…However, at 7 T the in vivo T 2 values reported by Scheenen et al (Scheenen et al , 2011) for young healthy volunteers were notably lower (PZ: 64 ms, transition zone: 50 ms). In this study it was found that T 1 , T 2 and ADC were higher in CG than PZ (significantly so for T 2 ), which is in contradiction to previous data (Gibbs et al , 2001; Foltz et al , 2011; Foltz et al , 2010a; Scheenen et al , 2011) where PZ exceeded CG in all parameters. However, while at 1.5 T T 1 was higher in PZ than CG (Foltz et al , 2011), in 7 T T 1 -weighted in vivo imaging there was no contrast between PZ and CG in (Scheenen et al , 2011).…”

“…In line with expectation, the T 1 times were substantially longer at 7 T than those reported at 1.5 T (Foltz et al , 2011), and the T 2 values were comparable to those reported at lower field strength (Foltz et al , 2010a; Gibbs et al , 2001; Langer et al , 2009). However, at 7 T the in vivo T 2 values reported by Scheenen et al (Scheenen et al , 2011) for young healthy volunteers were notably lower (PZ: 64 ms, transition zone: 50 ms).…”

Evaluation of T1 relaxation time in prostate cancer and benign prostate tissue using a Modified Look-Locker inversion recovery sequence

“…In 1987, Kjaer et al were not able to detect significant differences in T1 between PCa and benign prostate hyperplasia in 18 patients using six inversion recovery sequences with a fixed TR and different inversion times (TI) and a 1.5 T magnet 15 . Foltz et al found significantly shorter T1 in PCa lesions compared to normal appearing prostate tissue in 13 patients using a magnetization-prepared spiral technique and a 1.5 T magnet 16 . More recently, Ma et al used MR fingerprinting 36 and a 3 T magnet to quantitatively measure T1 on non-contrast-enhanced MRI in 109 PCa lesions and normal appearing prostate tissue in the PZ 17 .…”

“…In the context of cardiovascular imaging, T1 mapping has been established as an essential tool for characterization of myocardial tissue including the quantification of amyloidosis and detection of inflammatory myopathy 13,14 . Few studies have evaluated its value for prostate imaging with mixed results using different technical approaches [15][16][17] .…”

Decision support system for localizing prostate cancer based on multiparametric magnetic resonance imaging

“…In addition, although not often reported, we observed a small, but statistically significant, difference between the mean T 1values of cancerous and noncancerous regions consistent with a recent publication. 36 For individual sequence evaluation, the order in terms of performance was ADC > DCE > NT2W > T 1 as seen in Fig. 7.…”