Prostate-Specific Membrane Antigen (PSMA) Avid Pancreatic Neuroendocrine Tumor

Abstract

Ga-PSMA PET/CT is increasingly used to evaluate recurrent prostatic malignancy due to its high specificity. A 75-year-old man with a previous history of treated prostate cancer 3 years earlier presented with rising prostate-specific antigen (PSA) level and underwent Ga-PSMA PET/CT which demonstrated a PSMA-avid focus in the neck of the pancreas. Triple-phase abdominal CT demonstrated enhancement in the arterial phase and to a lesser extent the venous phase of a soft tissue mass in the neck of the pancreas. Cytological and histopathological examination of the soft tissue mass confirmed a low-grade pancreatic neuroendocrine tumor.

Incidental Detection of Head and Neck Squamous Cell Carcinoma on 68Ga-PSMA-11 PET/CT

“…9 The case presented here demonstrates that 68 Ga-PSMA-11 PET/CT can detect head and neck squamous cell carcinoma. Our case further highlights that PSMA is not as specific as originally believed and uptake can be found in many other types of neoplasms [5][6][7][8][9][10][11][12][13][14][15] as well as benign pathologies. [16][17][18][19]…”

Molecular imaging reporting and data systems (MI-RADS): a generalizable framework for targeted radiotracers with theranostic implications

“…PSMA-avid tumor other than PCa includes multiple myeloma, papillary or follicular thyroid carcinoma, pancreatic NET, or renal cell carcinoma [ 38 – 43 ]. For further details regarding pitfalls with PSMA-targeted PET probes, please refer to [ 10 ].…”

Nonspecific uptake of 68Ga-prostate-specific membrane antigen in diseases other than prostate malignancy on positron emission tomography/computed tomography imaging: A pictorial assay and review of literature

“…[ Table 2 ]. [ 21 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 ] The 68 Ga-labeled PSMA avidity in these various nonprostatic malignancies has been ascribed to the PSMA expression in the endothelial cells of the tumor neovasculature.…”