Prostate Specific Antigen Variation in Patients Without Clinically Evident Prostate Cancer

Luján, Marcos; Páez, Álvaro; Sánchez, Ernesto Sánchez; Herrero, Agustín; Martín, Eduardo; Berenguer, Antonio

doi:10.1097/00005392-199910000-00017

Cited by 10 publications

(11 citation statements)

References 7 publications

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“…We subsequently back-calculated the CV b by subtracting CV a from CV t : CV b ϭ ͌ CV t 2 Ϫ CV a 2 (7 ). Fifteen studies reported considerable variability of serial tPSA concentrations, but it was impossible to derive the CV b because of sufficient information on CV t and CV a was lacking (33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47).…”

Section: Biological Variation Estimatesmentioning

confidence: 99%

Biological Variation of Total Prostate-Specific Antigen: A Survey of Published Estimates and Consequences for Clinical Practice

Sölétormos¹,

et al. 2005

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Background:The objectives of this study were to determine whether a single result for total prostate-specific antigen (tPSA) can be used confidently to guide the need for prostate biopsy and by how much serial tPSA measurements must differ to be significant. tPSA measurements include both analytical and biological components of variation. The European Group on Tumor Markers conducted a literature survey to determine both the magnitude and impact of biological variation on single, the mean of replicate, and serial tPSA measurements. Methods: The survey yielded 27 studies addressing the topic, and estimates for the biological variation of tPSA could be derived from 12 of these studies. Results: The mean biological variation was 20% in the concentration range 0.1-20 g/L for men over 50 years. The biological variation means that the one-sided 95% confidence interval (CI) of the dispersion for a single tPSA

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Section: Biological Variation Estimatesmentioning

confidence: 99%

Biological Variation of Total Prostate-Specific Antigen: A Survey of Published Estimates and Consequences for Clinical Practice

Sölétormos¹,

et al. 2005

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“…A previous study conducted by this group reported the coefficient of variation to be in the order of 10% 4 and others give figures of 15%. 5 The current study used the value of 10% to determine the number of patients who had a fall in their PSA level, which was greater than would be expected through normal PSA variation. For each patient a critical value was calculated, above which the reduction would be considered to be significant.…”

Section: Significance Of the Drop In Psa Levelmentioning

confidence: 99%

An elevated PSA, which normalizes, does not exclude the presence of prostate cancer

Boddy

Pike

Al-Hayek

et al. 2005

Prostate Cancer Prostatic Dis

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The purpose of this study was to determine the incidence of prostate cancer in patients who have an elevated referral prostate-specific antigen (PSA), which subsequently falls to within their normal age-specific reference range prior to prostate biopsy. The study demonstrated that of the 160 patients recruited, 21 (13%) had a repeat PSA level which had fallen back to within their normal range. Five of these 21 patients (24%) were diagnosed with prostate cancer following biopsy, two of whom had a benign prostate examination. The study, therefore, demonstrates that normalisation of the PSA level prior to biopsy does not exclude the presence of prostate cancer even when the prostate feels benign.

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“…In another more recent study, long-term PSA variation was investigated in a large screening population of men without prostate cancer. 9 The coefficient of variability was significantly higher (18%) if only two vs three PSA measurements were done. However, individual variability was not dependent on the interval between PSA measurements.…”

Section: Discussionmentioning

confidence: 94%

Use of early PSA velocity to predict eventual abnormal PSA values in men at risk for prostate cancer

Riffenburgh

Amling

2003

Prostate Cancer Prostatic Dis

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Prostate Specific Antigen Variation in Patients Without Clinically Evident Prostate Cancer

Abstract: PSA velocity is within normal limits in almost all men (more than 95%) without clinically relevant prostate cancer. PSA individual variability is not fully dependent on the time between measurements when intervals are long, and can be substantially decreased with a third PSA sample.

Cited by 10 publications

References 7 publications

Biological Variation of Total Prostate-Specific Antigen: A Survey of Published Estimates and Consequences for Clinical Practice

Biological Variation of Total Prostate-Specific Antigen: A Survey of Published Estimates and Consequences for Clinical Practice

An elevated PSA, which normalizes, does not exclude the presence of prostate cancer

Use of early PSA velocity to predict eventual abnormal PSA values in men at risk for prostate cancer

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