Abstract:Objective: Determine how serum prostate-specific antigen (t-PSA) levels and free PSA (f/t PSA) ratio change following transurethral resection of the prostate (TURP). Results: Clinical improvement after TURP, reflected by I-PSS score, was demonstrated as early as 30 days and remained stable until the end of the follow-up. Mean t-PSA declined 71% after TURP and 60 days after surgery the reduction reached its peak, stabilizing afterwards. It varied from 6.19 ± 7.06 ng/mL before surgery to 1.75 ± 1.66 ng/mL on day… Show more
“…Studies have shown that PSA decreases drastically in patients who undergo TURP. Fonseca et al (16), showed that mean PSA levels declined 71% after TURP, and 60 days after surgery the reduction reached its peak, stabilizing afterwards. Mean PSA varied from 6.1 ng/mL before surgery to 1.7 ng/mL after 60 days postoperatively.…”
Objective: To assess the impact of the percent of resected tissue on the improvement of urinary symptoms.
Materials and Methods:The study included a prospective analysis of 88 men with benign prostatic hyperplasia. Patients were divided in three groups according to the percent of resected tissue: Group 1 < 30%; Group 2, 30% to 50%; and Group 3, > 50%. Each patient was re-evaluated 3 months after surgery. We assessed the international prostatic symptom score, nocturia and serum prostate specific antigen levels. Results: All patients presented a significant decrease on mean International Prostate System Score (IPSS) (23 to 5.9), Quality of Life (QoL) (4.9 to 1.0) and nocturia (3.2 to 1.9). Variation in the IPSS was 16.7, 16.6 and 18.4 for patients from Group 1, 2 and 3 respectively (P = 0.504). Although the three groups presented a significant decrease in QoL, patients in Group 3 presented a significantly greater decrease when compared to Group 1. Variation in QoL was 3.1, 3.9 and 4.2 for patients from Group 1, 2 and 3 respectively (p = 0.046). There was no significant difference in nocturia variation according to the percent of resected tissue (p = 0.504). Median pre and postoperative PSA value was 3.7 and 1.9 ng/mL respectively. Patients from Group 1 did not show a significant variation (p = 0.694). Blood transfusions were not required in any group. Conclusions: Resection of less than 30% of prostatic tissue seems to be sufficient to alleviate lower urinary tract symptoms related to benign prostate hyperplasia. However, these patients may not show a significant decrease in serum PSA level.
“…Studies have shown that PSA decreases drastically in patients who undergo TURP. Fonseca et al (16), showed that mean PSA levels declined 71% after TURP, and 60 days after surgery the reduction reached its peak, stabilizing afterwards. Mean PSA varied from 6.1 ng/mL before surgery to 1.7 ng/mL after 60 days postoperatively.…”
Objective: To assess the impact of the percent of resected tissue on the improvement of urinary symptoms.
Materials and Methods:The study included a prospective analysis of 88 men with benign prostatic hyperplasia. Patients were divided in three groups according to the percent of resected tissue: Group 1 < 30%; Group 2, 30% to 50%; and Group 3, > 50%. Each patient was re-evaluated 3 months after surgery. We assessed the international prostatic symptom score, nocturia and serum prostate specific antigen levels. Results: All patients presented a significant decrease on mean International Prostate System Score (IPSS) (23 to 5.9), Quality of Life (QoL) (4.9 to 1.0) and nocturia (3.2 to 1.9). Variation in the IPSS was 16.7, 16.6 and 18.4 for patients from Group 1, 2 and 3 respectively (P = 0.504). Although the three groups presented a significant decrease in QoL, patients in Group 3 presented a significantly greater decrease when compared to Group 1. Variation in QoL was 3.1, 3.9 and 4.2 for patients from Group 1, 2 and 3 respectively (p = 0.046). There was no significant difference in nocturia variation according to the percent of resected tissue (p = 0.504). Median pre and postoperative PSA value was 3.7 and 1.9 ng/mL respectively. Patients from Group 1 did not show a significant variation (p = 0.694). Blood transfusions were not required in any group. Conclusions: Resection of less than 30% of prostatic tissue seems to be sufficient to alleviate lower urinary tract symptoms related to benign prostate hyperplasia. However, these patients may not show a significant decrease in serum PSA level.
“…It has been reported that sub-clinical hyperthyroidism is not associated with CHD or mortality from cardiovascular causes [4] but it is sufficient to induce an increase in atrial fibrillation rate [5] and increased factor X activity in patients with subclinical hyperthyroidism represents a potential hypercoagulable state [6]. It has also been reported that serum prostate-specific antigen (PSA) decreases drastically in patients who undergo transurethral resection of the prostate (TURP) [7]. We present a case of paroxysmal atrial fibrillation during acute myocardial infarction associated with subclinical hyperthyroidism, severe three vessels coronary artery disease and elevation of PSA after TURP in a 78-year-old Italian man.…”
“…In larger prostates, it has also been shown that PSA can be reduced by 90% [ 23 ], an amount similar to that achieved with open prostatectomy. A recent study demonstrated that PSA is reduced by 71% after TURP [ 24 ]. In contrast, PSA is only reduced by 30%-42% after ablation with a potassium-titanyl-phosphate (KTP) laser [ 25 , 26 ].…”
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