Prostate-specific antigen associates with extensive lymph node invasion in high-risk prostate cancer

Porcaro, Antonio Benito; Corsi, Paolo; Inverardi, Davide; Sebben, Marco; Tafuri, Alessandro; Processali, Tania; Mattevi, Daniele; Marchi, Davide De; Pirozzi, Marco; Cerruto, Maria Angela; Amigoni, Nelia; Rizzetto, Riccardo; Brunelli, Matteo; Siracusano, Salvatore; Artibani, Walter

doi:10.1177/0300891618765567

Cited by 3 publications

(2 citation statements)

References 25 publications

(42 reference statements)

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“…The AUA/ASTRO/SUO guideline recommends radical prostatectomy as one of the standard treatments in this group and this should be accompanied by PLND assuming an estimated 15-40% LNI rate (6). PLND candidates may be selected based on clinical information such as serum PSA levels, Gleason score and estimated tumor volume (5,7).…”

Section: Introductionmentioning

confidence: 99%

Pelvic lymph node dissection in high-risk prostate cancer

Haiquel¹,

Cathelineau

Sánchez-Salas

et al. 2022

Int. braz j urol.

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Introduction:The therapeutic role of pelvic lymph node dissection (PLND) in prostate cancer (PCa) is unknown due to absence of randomized trials. Objective: to present a critical review on the therapeutic benefi ts of PLND in high risk localized PCa patients. Materials and Methods: A search of the literature on PLND was performed using PubMed, Cochrane, and Medline database. Articles obtained regarding diagnostic imaging and sentinel lymph node dissection, PLND extension, impact of PLND on survival, PLND in node positive "only" disease and PLND surgical risks were critically reviewed. Results: High-risk PCa commonly develops metastases. In these patients, the possibility of presenting lymph node disease is high. Thus, extended PLND during radical prostatectomy may be recommended in selected patients with localized high-risk PCa for both accurate staging and therapeutic intent. Although recent advances in detecting patients with lymph node involvement (LNI) with novel imaging and sentinel node dissection, extended PLND continues to be the most accurate method to stage lymph node disease, which may be related to the number of nodes removed. However, extended PLND increases surgical time, with potential impact on perioperative complications, hospital length of stay, rehospitalization and healthcare costs. Controversy persists on its therapeutic benefi t, particularly in patients with high node burden. Conclusion:The impact of PLND on biochemical recurrence and PCa survival is unclear yet. Selection of patients may benefi t from extended PLND but the challenge remains to identify them accurately. Only prospective randomized study would answer the precise role of PLND in high-risk pelvis confi ned PCa patients.

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Section: Introductionmentioning

confidence: 99%

Pelvic lymph node dissection in high-risk prostate cancer

Haiquel¹,

Cathelineau

Sánchez-Salas

et al. 2022

Int. braz j urol.

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“…Для прогноза течения заболевания и предсказания развития рецидива РПЖ после РПЭ в клинической практике используют такие показатели, как уровень и плотность сывороточного простатического специфического антигена (ПСА), патологоанатомическая стадия заболевания, оценка по шкале Глисона, характер хирургического края, объем опухоли, наличие/отсутствие лимфоваскулярной и периневральной инвазий [4]. Однако данные показатели характеризуются низкими чувствительностью и специфичностью [5,6].…”

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Dynamics of miRNA expression in urine extracellular vesicles of prostate cancer patients after radical prostatectomy

Shutko,

Bryzgunova,

Ostal’cev

et al. 2024

Usp. mol. onkol

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Introduction. It is known that the treatment of oncological diseases including prostate cancer (PCa) causes changes in the expression of oncogenic and oncosuppressive miRNAs. The analysis of miRNA expression dynamics can be used to predict the course of the disease and its response to therapy. However, the effect of PCa therapy on the expression of extracellular miRNAs is just beginning to be investigated.Aim. To study the expression dynamics of 14 miRNAs (miR-19b, -22-3p, -30e, -31, -92a, -125b, -144, -200b, -205, -222, -375, -378a, -425, -660) in urine extracellular vesicles of PCa patients after radical prostatectomy and to reveal prognostic miRNA ratios.Materials and methods. Urine samples of 18 donors and 18 PCa patients, obtained before radical prostatectomy, 1 week and 3 months after surgery, were examined. Extracellular vesicles were isolated by aggregation-precipitation protocol; extracellular vesicles miRNAs were isolated using fiberglass sorbents and octane acid. Data on threshold detection cycles of 14 miRNAs were obtained using reverse transcription – loop polymerase chain reaction (TaqMan).Results. It was found that prostatectomy causes a significant change in the relative expression of 44 miRNA ratios in the urine of PCa patients. Four groups of miRNA ratios can be distinguished: 1) miRNA ratios, which expression level significantly differed between donors and PCa patients before surgery and significantly changed in PCa patients 3 months after prostatectomy in the direction of the level of donors (6 pairs); 2) miRNA ratios, which expression did not significantly differ between donors and PCa patients before surgery, but significantly differed from the baseline in PCa patients and donors 3 months after prostatectomy (5 pairs); 3) miRNA ratios, based on expression ratios of which PCa patients can be divided into two or three significantly different subgroups 3 months after prostatectomy (19 pairs); 4) miRNA ratios that did not significantly change their expression after prostatectomy (30 pairs).Conclusion. Prostatectomy causes a significant change in the level of expression of miRNA in urine. 6 pairs of miRNAs, the relative expression of which after surgery significantly changed towards that of healthy donors and 19 pairs of miRNAs, according to the level of relative expression of which patients with prostate cancer were divided into two significantly different subgroups 3 months after prostatectomy, were identified based on the analysis of the dynamics of miRNA expression after prostatectomy.

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Body Mass Index and prostatic-specific antigen are predictors of prostate cancer metastases in patients undergoing robot-assisted radical prostatectomy and extended pelvic lymph node dissection

Porcaro

Tafuri

Sebben

et al. 2019

Minerva Urol Nefrol

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Prostate-specific antigen associates with extensive lymph node invasion in high-risk prostate cancer

Abstract: PSA was the only independent predictor of extensive LNI and could be an important preoperative factor for stratifying high-risk patients.

Cited by 3 publications

References 25 publications

Pelvic lymph node dissection in high-risk prostate cancer

Pelvic lymph node dissection in high-risk prostate cancer

Dynamics of miRNA expression in urine extracellular vesicles of prostate cancer patients after radical prostatectomy

Body Mass Index and prostatic-specific antigen are predictors of prostate cancer metastases in patients undergoing robot-assisted radical prostatectomy and extended pelvic lymph node dissection

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