Prostate perfusion mapping using Fourier‐transform based velocity‐selective arterial spin labeling: Choice of cutoff velocity and comparison with brain

Liu, Dapeng; Zhu, Dan; Xu, Feng; Sedaghat, Farzad; Qin, Qin

doi:10.1002/mrm.29695

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…Both rTBV and rTBF, derived by either DSC or VSASL, showed high diagnostic accuracy for grading gliomas from the ROC curves. The superior performance of rTBV derived from VSASL compared to that of rTBF shown in this work can be partly attributed to the fact that the spin-labeling technique for CBV mapping is able to deliver higher SNR than CBF mapping [26,27] as the labeled blood signal does not experience T 1 decay when PLD is set to zero.…”

Section: Discussionmentioning

confidence: 99%

Tumor Blood Volume Measurement in Brain Gliomas Using Velocity-Selective Arterial Spin Labeling

Qu,

Ma,

Yan

et al. 2024

Preprint

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Background To evaluate the feasibility and performance of velocity selective (VS) ASL based cerebral blood volume (CBV) mapping among glioma patients in clinical practice, comparing with the VSASL based cerebral blood flow (CBF) mapping and dynamic susceptibility contrast-enhanced perfusion-weighted imaging (DSC-PWI). Methods This study included patients with histologically proven brain glioma who underwent preoperative MRI including VSASL based CBV, CBF and DSC-PWI between 2017 and 2021. Visual inspection was performed to evaluate the lesion conspicuity on VSASL derived CBV maps based on 1–3 criteria by comparing to the surrounding parenchyma. The relative values of maximum tumor blood volume (rTBV) and tumor blood flow (rTBF), derived from VSASL or DSC-PWI were compared between low-grade and high-grade glioma. Linear regression and Bland–Altman analyses were constructed to evaluate the correlation and agreement of rTBV measurements between VSASL method and DSC-PWI. The diagnosis ability for discrimination between low- and high-grade glioma were evaluated using ROC curves. Results Forty-eight participants (mean age, 45 ± 13 years; 25 men; 23 high-grade gliomas) were evaluated. The lesion conspicuity of VSASL based CBV maps was good on visual inspection (averaged scores: 2.26 ± 0.76, weighted kappa of 0.8 between readers). Moreover, VSASL provided highly correlated quantifications of rTBV (R2 = 0.83, p < 0.001) compared to DSC-PWI, and further improved diagnostic performance than VSASL derived rTBF measurements (ROC AUC = 0.94 vs. 0.89). Conclusions VSASL served as a promising and accurate means in quantification of TBV for glioma stratification in clinical patients, indicating its potential as a viable non-contrast alternative to DSC-PWI for brain tumor applications.

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Section: Discussionmentioning

confidence: 99%

Tumor Blood Volume Measurement in Brain Gliomas Using Velocity-Selective Arterial Spin Labeling

Qu,

Ma,

Yan

et al. 2024

Preprint

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“…A dynamic phase-cycling scheme for VSASL was proposed to further ensure both velocity and spatial responses robust to field inhomogeneities [27]. Moreover, the effectiveness of FT-VS labeling has been demonstrated for mapping CBV [28][29][30][31], venous oxygenation [32], MR angiography [33][34][35][36][37], and with a commercial perfusion phantom [38]. Other groups have also confirmed better performance in detecting perfusion signal changes under brain stimulus or with respect to temporal SNR by FT-VSI ASL than by PCASL [39][40][41].…”

Section: Introductionmentioning

confidence: 95%

Velocity-Selective Arterial Spin Labeling Perfusion in Monitoring High Grade Gliomas Following Therapy: Clinical Feasibility at 1.5T and Comparison with Dynamic Susceptibility Contrast Perfusion

Lambrecht,

Liu,

Dzaye

et al. 2024

Brain Sciences

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MR perfusion imaging is important in the clinical evaluation of primary brain tumors, particularly in differentiating between true progression and treatment-induced change. The utility of velocity-selective ASL (VSASL) compared to the more commonly utilized DSC perfusion technique was assessed in routine clinical surveillance MR exams of 28 patients with high-grade gliomas at 1.5T. Using RANO criteria, patients were assigned to two groups, one with detectable residual/recurrent tumor (“RT”, n = 9), and the other with no detectable residual/recurrent tumor (“NRT”, n = 19). An ROI was drawn to encompass the largest dimension of the lesion with measures normalized against normal gray matter to yield rCBF and tSNR from VSASL, as well as rCBF and leakage-corrected relative CBV (lc-rCBV) from DSC. VSASL (rCBF and tSNR) and DSC (rCBF and lc-rCBV) metrics were significantly higher in the RT group than the NRT group allowing adequate discrimination (p < 0.05, Mann–Whitney test). Lin’s concordance analyses showed moderate to excellent concordance between the two methods, with a stronger, moderate correlation between VSASL rCBF and DSC lc-rCBV (r = 0.57, p = 0.002; Pearson’s correlation). These results suggest that VSASL is clinically feasible at 1.5T and has the potential to offer a noninvasive alternative to DSC perfusion in monitoring high-grade gliomas following therapy.

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Direct angiographic comparison of different velocity‐selective saturation, inversion, and DANTE labeling modules on cerebral arteries

Liu,

Zhu,

Qin

2024

Magnetic Resonance in Med

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PurposeThis study evaluated the velocity‐selective (VS) MRA with different VS labeling modules, including double refocused hyperbolic tangent, eight‐segment B1‐insensitive rotation, delay alternating with nutation for tailored excitation, Fourier transform–based VS saturation, and Fourier transform–based inversion.MethodsThese five VS labeling modules were evaluated first through Bloch simulations, and then using VSMRA directly on various cerebral arteries of healthy subjects. The relative signal ratios from arterial ROIs and surrounding tissues as well as relative arteria‐tissue contrast ratios of different methods were compared.ResultsDouble refocused hyperbolic tangent and eight‐segment B1‐insensitive rotation showed very similar labeling effects. Delay alternating with nutation for tailored excitation yielded high arterial signal but with residual tissue signal due to the spatial banding effect. Fourier transform–based VS saturation with half the time of other techniques serves as an efficient nonsubtractive VSMRA method, but the remaining tissue signal still obscured some small distal arteries that were delineated by other subtraction‐based VSMRA, allowing more complete cancelation of static tissue. Fourier transform–based inversion produced the highest arterial signal in VSMRA with minimal tissue background.ConclusionThis is the first study that angiographically compared five different VS labeling modules. Their labeling characteristics on arteries and tissue and implications for VSMRA and VS arterial spin labeling are discussed.

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Prostate perfusion mapping using Fourier‐transform based velocity‐selective arterial spin labeling: Choice of cutoff velocity and comparison with brain

Cited by 4 publications

References 36 publications

Tumor Blood Volume Measurement in Brain Gliomas Using Velocity-Selective Arterial Spin Labeling

Tumor Blood Volume Measurement in Brain Gliomas Using Velocity-Selective Arterial Spin Labeling

Velocity-Selective Arterial Spin Labeling Perfusion in Monitoring High Grade Gliomas Following Therapy: Clinical Feasibility at 1.5T and Comparison with Dynamic Susceptibility Contrast Perfusion

Direct angiographic comparison of different velocity‐selective saturation, inversion, and DANTE labeling modules on cerebral arteries

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