Prostate: MR imaging with an endorectal surface coil.

Schnall, Mitch; Lenkinski, Robert E.; Pollack, Howard; Imai, Yutaka; Kressel, Herbert Y.

doi:10.1148/radiology.172.2.2748842

Cited by 214 publications

(77 citation statements)

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“…In the future, we anticipate improving anatomic resolution by (i) enhanced sensitivity through localized coils (up to 10-fold increase in SNR) (38)(39)(40); (ii) improved polarization methods, which include optimizing solvent, radical, and gadolinium-chelate (a potential fourfold increase in SNR if we obtain polarization similar to that of [1-13 C] pyruvate) (41); and (iii) MR techniques including more efficient sampling of k-space in order to reduce losses from T 1 and T 2 relaxation (42, 43). The advantages of better coil design are highlighted by the development of the endorectal coil that is the current standard for MR imaging of the prostate (40,44), and murine brain studies in particular would benefit from dedicated head coils. These improvements in polarization and acquisition techniques would significantly improve the spatial resolution obtained, reducing partial volume effects and allowing a more detailed evaluation of specific tissues.…”

Section: Discussionmentioning

confidence: 99%

Hyperpolarized ¹³ C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging

Keshari

Kurhanewicz

Bok

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

149

159

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Reduction and oxidation (redox) chemistry is involved in both normal and abnormal cellular function, in processes as diverse as circadian rhythms and neurotransmission. Intracellular redox is maintained by coupled reactions involving NADPH, glutathione (GSH), and vitamin C, as well as their corresponding oxidized counterparts. In addition to functioning as enzyme cofactors, these reducing agents have a critical role in dealing with reactive oxygen species (ROS), the toxic products of oxidative metabolism seen as culprits in aging, neurodegenerative disease, and ischemia/ reperfusion injury. Despite this strong relationship between redox and human disease, methods to interrogate a redox pair in vivo are limited. Here we report the development of [1-13 C] dehydroascorbate [DHA], the oxidized form of Vitamin C, as an endogenous redox sensor for in vivo imaging using hyperpolarized 13 C spectroscopy. In murine models, hyperpolarized [1-13 C] DHA was rapidly converted to [1-13 C] vitamin C within the liver, kidneys, and brain, as well as within tumor in a transgenic prostate cancer mouse. This result is consistent with what has been previously described for the DHA/Vitamin C redox pair, and points to a role for hyperpolarized [1-13 C] DHA in characterizing the concentrations of key intracellular reducing agents, including GSH. More broadly, these findings suggest a prognostic role for this new redox sensor in determining vulnerability of both normal and abnormal tissues to ROS.MRI | molecular imaging | probe | kinetics

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Section: Discussionmentioning

confidence: 99%

Hyperpolarized ¹³ C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging

Keshari

Kurhanewicz

Bok

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

149

159

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“…The coil was tuned to a value near the resonance frequency of 63.8 MHz by placing a capacitor across the coil within the balloon. The physical properties of this coil have been described previously [9]. The patients received 20 mg of scopolamine butylbromide (Boehringer Tanabe, Japan) by intramuscular injection before examination.…”

Section: Methodsmentioning

confidence: 99%

“…A wide range has been reported for the accuracy of staging by CT (40±92%) [1±5] and for conventional and contrast material-enhanced MRI (50± 96%) [1±8]. Over the past decade, MRI with an endorectal surface coil has been used to improve the accuracy of the preoperative staging of prostatic carcinoma [9,10]. We have used MRI with an endorectal surface coil to stage bladder tumours and noted a markedly enhanced layer within the bladder wall after administering Gd-DTPA.…”

Section: Introductionmentioning

confidence: 99%

A new staging criterion for bladder carcinoma using gadolinium‐enhanced magnetic resonance imaging with an endorectal surface coil: a comparison with ultrasonography

Hayashi¹,

Tochigi

Shiraishi³

et al. 2000

BJU International

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Objective To evaluate the accuracy of a new staging criterion, submucosal linear enhancement (SLE) on gadolinium-diethylenetriamine-pentaacetic acidenhanced T1-weighted magnetic resonance imaging (MRI) using an endorectal surface coil (endorectal enhanced MRI), and to compare the accuracy of this method with that of transurethral ultrasonography (TUUS). Patients and methods The study included 71 patients with bladder tumours (63 men and eight women, mean age 65.5 years, range 31±85). The SLE coincided with abundant submucosal vascular beds, as reported in a previous study. When the SLE beneath the tumour maintained continuity, the tumour was diagnosed as super®cial (fT1), but if the SLE was interrupted by the tumour, the disease was considered invasive (oT2a). Super®cial muscle invasion (less than half the muscle layer) and deep muscle invasion (more than half the muscle layer) were classi®ed as T2a and T2b, respectively. When the tumour formed an extravesical mass, the tumour was classi®ed as T3b. Results The staging accuracy for bladder tumours using SLE on endorectal-enhanced MRI or TUUS was 83% and 60%, respectively (P<0.01). Using the SLE, muscle invasion of bladder tumour was diagnosed with an accuracy of 87%, a sensitivity of 91% and a speci®city of 87%; this was signi®cantly better than with TUUS (P<0.01). Conclusion The criterion of SLE on Gd-DTPA enhanced T1-weighted MRI using an endorectal surface coil is useful for staging bladder tumour, and the staging accuracy is signi®cantly better than with TUUS.

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“…1) (25,26). On T2-weighted MRI, regions of prostate cancer demonstrate decreased signal intensity relative to normal peripheral zone tissue due to increased cell density and a loss of the prostatic ducts ( Fig.…”

Section: Morphologic Identification Of Prostate Cancer-mrimentioning

confidence: 99%

Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer

Kurhanewicz

Swanson

Nelson

et al. 2002

Magnetic Resonance Imaging

332

266

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Magnetic resonance spectroscopic imaging (MRSI) provides a noninvasive method of detecting small molecular markers (historically the metabolites choline and citrate) within the cytosol and extracellular spaces of the prostate, and is performed in conjunction with high-resolution anatomic imaging. Recent studies in pre-prostatectomy patients have indicated that the metabolic information provided by MRSI combined with the anatomical information provided by MRI can significantly improve the assessment of cancer location and extent within the prostate, extracapsular spread, and cancer aggressiveness. Additionally, pre-and post-therapy studies have demonstrated the potential of MRI/MRSI to provide a direct measure of the presence and spatial extent of prostate cancer after therapy, a measure of the time course of response, and information concerning the mechanism of therapeutic response. In addition to detecting metabolic biomarkers of disease behavior and therapeutic response, MRI/MRSI guidance can improve tissue selection for ex vivo analysis. High-resolution magic angle spinning ( 1 H HR-MAS) spectroscopy provides a full chemical analysis of MRI/MRSI-targeted tissues prior to pathologic and immunohistochemical analyses of the same tissue. Preliminary 1 H HR-MAS spectroscopy studies have already identified unique spectral patterns for healthy glandular and stromal tissues and prostate cancer, determined the composition of the composite in vivo choline peak, and identified the polyamine spermine as a new metabolic marker of prostate cancer. The addition of imaging sequences that provide other functional information within the same exam (dynamic contrast uptake imaging and diffusion-weighted imaging) have also demonstrated the potential to further increase the accuracy of prostate cancer detection and characterization.

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Prostate: MR imaging with an endorectal surface coil.

Cited by 214 publications

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Hyperpolarized ¹³ C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging

Hyperpolarized ¹³ C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging

A new staging criterion for bladder carcinoma using gadolinium‐enhanced magnetic resonance imaging with an endorectal surface coil: a comparison with ultrasonography

Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer

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Prostate: MR imaging with an endorectal surface coil.

Cited by 214 publications

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Hyperpolarized 13 C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging

Hyperpolarized 13 C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging

A new staging criterion for bladder carcinoma using gadolinium‐enhanced magnetic resonance imaging with an endorectal surface coil: a comparison with ultrasonography

Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer

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Product

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Hyperpolarized ¹³ C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging

Hyperpolarized ¹³ C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging