Prostate Metastasis of Malignant Melanoma

Balaban, Muhsin; Selimoglu, Ahmet; Horuz, Rahim; Akça, Oktay; Albayrak, Selami

doi:10.4111/kju.2013.54.7.486

Cited by 6 publications

(4 citation statements)

References 7 publications

(7 reference statements)

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“…9 In addition, case reports have documented metastases of various tumor types to the prostate, including (but not limited to) small cell carcinoma of the lung, seminoma, nonseminomatous germ cell tumors, renal cell carcinoma, and esophageal adenocarcinoma. 7,[10][11][12][13][14][15][16][17] However, because these reports registered only individual occurrences, the frequency and distribution of the different tumor types that metastasize to the prostate was thus far unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Another study of 9 cases of colorectal adenocarcinoma involving the prostate included 3 patients in whom prostatic involvement was the initial clinical presentation, subsequently leading to the discovery of the primary tumor 9. In addition, case reports have documented metastases of various tumor types to the prostate, including (but not limited to) small cell carcinoma of the lung, seminoma, nonseminomatous germ cell tumors, renal cell carcinoma, and esophageal adenocarcinoma 7,10–17. However, because these reports registered only individual occurrences, the frequency and distribution of the different tumor types that metastasize to the prostate was thus far unclear.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathologic Spectrum of Secondary Solid Tumors of the Prostate of Nonurothelial Origin

Acosta¹,

Gordetsky

Collins

et al. 2022

American Journal of Surgical Pathology

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Secondary involvement of the prostate by urothelial or hematolymphoid neoplasms is relatively common and well-described. In contrast, less is known about the clinicopathologic spectrum of secondary solid tumors of the prostate of nonurothelial origin. This study evaluated a series of secondary nonurothelial solid tumors of the prostate diagnosed at 21 institutions. Eighty-five patients with a median age at diagnosis of 64 years were included. Sixty-two patients had clinically manifest disease (62/85, 73%), 10 were diagnosed incidentally (10/85, 12%), and 13 (13/85, 15%) had no detailed clinical data available about symptomatology at presentation. Among patients with clinically manifest disease, the most common symptoms and signs were lower urinary tract symptoms (either obstructive of irritative; 36/62, 58%), abdominal or pelvic pain or discomfort (16/62, 26%), and hematuria (12/62, 19%). Metastasis and direct invasion occurred at roughly similar frequencies (47% vs. 42%) in this series, and in 11% of the cases, the mechanism of spread to the prostate was unclear/uncertain. Overall, among tumors with confirmed sites of origin, the most common primary sites were gastrointestinal tract (53/85, 62%), lung (9/85, 11%), skin (6/85, 7%), and testis (4/85, 5%). Among metastases, the most common tumor types were lung carcinomas (9/40, 23%), colorectal adenocarcinomas (7/40, 18%), melanoma (6/40, 15%), and germ cell tumors (6/40, 15%). This study demonstrated that secondary involvement of the prostate by solid tumors of nonurothelial origin is commonly symptomatic and that the most frequent sites of origin are the gastrointestinal tract, lung, skin, and testis. These findings are worth considering when lesions with unusual cytomorphology and/or architecture are encountered in prostate specimens.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinicopathologic Spectrum of Secondary Solid Tumors of the Prostate of Nonurothelial Origin

Acosta¹,

Gordetsky

Collins

et al. 2022

American Journal of Surgical Pathology

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“…Despite the incidental diagnosis of prostatic melanosis, it is crucial to differentiate it from primary and metastatic malignant melanomas. Balaban et al (11) have reported that 37% of malignant melanoma cases metastasize to the genitourinary system.…”

Section: Discussionmentioning

confidence: 99%

Prostatic Melanosis: Case Report

Teoman¹,

Sayğın²,

Munğan³

2019

JAREM

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Prostatic melanosis is a rare lesion characterized by melanocytic proliferation in the prostatic epithelium and stroma. This entity is absolutely benign and it is not a precursor for malignant melanoma. Yet, the pathogenesis of prostatic melanosis is not fully elucidated. Differential diagnosis of melanosis with primary and metastatic malignant melanoma is crucial because of the clinical manifestation and their biological nature differentiation. Here, we have presented a 67-year-old man who was diagnosed with prostatic melanosis with prostatic adenocarcinoma, and differential diagnosis with melanocytic lesions has been discussed.

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“…Primary and metastatic malignant melanoma must be considered in differfentail diagnosis. It should be keep in mind that 37% of malignant melanoma might be metastasis to genito-urinary system 10 .…”

Section: Discussi̇onmentioning

confidence: 99%