Prostate leiomyosarcoma: A rare tumor

Abstract

Leiomyosarcoma is a rare neoplasm with a poor survival rate. Between June 2018 to January 2019 we treated a rare case of Prostate Leiomyosarcoma initially metastatic to the lung and the liver with multiple pelviclymph nodes. Five cycles of chemotherapy and palliative radiotherapy have been delivered with a mean follow up of 1 year .Chestabdominal-pelvic CT scan with MRI and bone scan are necessarily to assess clinical staging. The objective of this study is to review our experience in the management of Prostate Leiomyosarcoma at the Casablanca Cancer Center of Mohammed VI University of Health Sciences with a literature review of this rare neoplasm.

Primary leiomyosarcoma of prostate: Report of 3 cases

“…Primary prostate leiomyosarcoma is the most common sarcoma affecting the prostate, although it is generally a rare tumor. 3 Leiomyosarcoma of prostate was described by Gaudin et al 4 in 1998. World Health Organization classifies this tumor as a distinct spindle cell neoplasm.…”

“…5,6 The etiology of primary prostate leiomyosarcoma is unknown or poorly understood. 3 Histological types can be divided into prostate leiomyosarcoma, rhabdomyosarcoma, fibrosarcoma and spindle cell sarcoma. Benali et al 3…”

“…3 Histological types can be divided into prostate leiomyosarcoma, rhabdomyosarcoma, fibrosarcoma and spindle cell sarcoma. Benali et al 3…”

“…Heddat et al 7 in their study stated that the most frequent reason for consultation is a urinary obstructive syndrome including hematuria, burning with urination, perineal pain, urgency, acute urine retention and weight loss as observed in our case. 3,[6][7][8][9] Patients typically present between the ages of 41 and 78 years (mean age 61 years). 1,10 Serum PSA levels are typically normal due to their nonepithelial origin, making it highly difficult to differentiate these from benign prostatic diseases.…”

“…1,14 The pathological diagnosis, supplemented by an immunohistochemical study is essential for the classification of these tumors. 3 Recommendations regarding the management of prostate sarcomas weren't sufficient and contradictory. Sen and associate evaluated the results of 13 patients treated at the Mayo Clinic between 1970 and 1985, 10 patients were treated for the cure: 3 with leiomyosarcoma, 2 with rhabdomyosarcoma and 5 with carcinosarcoma.…”