Prostate Cancers of Different Zonal Origin: Clinicopathological Characteristics and Biochemical Outcome After Radical Prostatectomy

Iremashvili, Viacheslav; Pelaez, Lisét; Jordà, Mercè; Manoharan, M.; Rosenberg, Daniel L.; Soloway, Mark S.

doi:10.1016/j.urology.2012.08.012

Cited by 32 publications

(38 citation statements)

References 24 publications

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“…Tumor volume of anterior cases distributed from 0.0041 to 22.4 cm 3 , with an average of 3.81 cm and a median volume of 2.74 cm 3 , and that of posterior cases distributed from 0.0026 to 26.8 cm 3 , with an average of 5.34 cm and a median of 3.74 cm. The posterior cases tend to be larger than anterior cases, although there was no statistical significance ( P = 0.0508).…”

Section: Resultsmentioning

confidence: 88%

“…The posterior cases tend to be larger than anterior cases, although there was no statistical significance ( P = 0.0508). Tumor volume of transition zone cases distributed from 0.0041 to 22.4 cm 3 , with an average of 4.10 cm and a median volume of 2.93 cm 3 , and that of peripheral zone cases distributed from 0.0026 to 26.8 cm 3 , with an average of 5.33 cm and a median of 3.27 cm ( P = 0.5318).…”

Section: Resultsmentioning

confidence: 95%

“…It is crucial to recognize cancer location in the prostate when determining treatment strategy. Thought to be common knowledge, we have understood that prostate cancer arises in the peripheral zone in a majority of cases; while the incidence of the cancer at the transition zone is rather low . Accordingly, the trans‐rectal approach has been a common method for prostate biopsy in current practice for patient care.…”

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confidence: 99%

“…According to these studies, the anterior cancer constituted only 10 to 30% of all prostate cancer . Transition zone cancer has been shown to be relatively small and has a low Gleason grade …”

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confidence: 99%

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Clinicopathological importance of anterior prostate cancer in Japanese Men

Sato

Takahashi

Kimura

et al. 2017

Pathology International

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Prostate cancer of transition zone origin or anterior location has been recognized as infrequent, smaller in size and indolent, whereas, our previous report showed that transition zone/anterior cancer was frequently experienced in Japanese men. The current study was conducted to show clinicopathological characteristics of transition zone/anterior cancer. A total of 201 radical prostatectomy specimens were categorized as cancer of anterior or posterior prostate where more than two thirds of the tumor existed in the specific area. Clinicopathological characteristics including Gleason score, pathological stage, lymph node metastasis, extraprostatic extension, surgical incision into the prostate (shown as pT2+), and surgical margin status were compared between anterior and posterior cases. Cases were divided as 83, 73, and 45 of anterior, posterior cancer, and no dominance, respectively. Anterior cancers included significant numbers of high grade tumors (13/83 cases: 15.7%), which was less than posterior cancers (28.8%: 21/73). The cases in pT2+ were significantly more frequent in anterior cases than posterior ones (22.9% vs. 4.1%). No seminal vesicle invasion was shown in anterior cases. Thus, although anterior cancers are less aggressive than posterior cancers, a significant numbers of clinically important cancers were located in the anterior portion in Japanese men.

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Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 95%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Clinicopathological importance of anterior prostate cancer in Japanese Men

Sato

Takahashi

Kimura

et al. 2017

Pathology International

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“…Bott et al [8] showed that about one fifth of all index cancers were located anterior to the prostatic urethra, highlighting the need for better understanding of the clinicopathologic features of these lesions. Recently, Al-Ahmadie et al [14] in 1,312 radical prostatectomies demonstrated that 197 (15%) PCa were located in the AZ of the gland and characterized by a superimposable grading and staging in comparison with PZ PCa; Iremashvili et al [22] reported a higher rate of positive surgical margin in the presence of TZ cancer in comparison with PZ PCa in 1,141 men submitted to radical prostatectomy. In the last years, magnetic resonance imaging and magnetic resonance imaging/ultrasound fusion-guided biopsy have increased the detection of PCa at repeat biopsy, with an estimated incidence equal to 30-50% of cases [5,6,7]; in this respect, transperineal prostate biopsy demonstrated a better accuracy in comparison with the transrectal approach in the diagnosis of AZ cancers [23].…”

Section: Discussionmentioning

confidence: 99%

Detection Rate of Anterior Prostate Cancer in 226 Patients Submitted to Initial and Repeat Transperineal Biopsy

et al. 2014

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Objective: To evaluate the detection rate of anterior zone (AZ) prostate cancer (PCa) in patients submitted to initial and repeat transperineal prostate biopsy. Methods: From January 2013 to August 2013, 226 patients (median age 64 years) with negative digital rectal examination underwent initial (144 cases) and repeat (82 cases) transperineal prostate biopsy for PSA >10 ng/ml, PSA 4.1-10.0 or 2.6-4.0 ng/ml with free/total PSA ≤25% and ≤20%, respectively. A median of 22 versus 32 cores were performed, including 4 cores of the AZ versus 6 cores (4 anterior plus 2 cores of the transition zone, TZ) at initial versus repeat biopsy, respectively. The detection rate of PCa of the peripheral zone (PZ), AZ and TZ was prospectively evaluated. Results: The median PSA was 7.6 ng/ml; overall, a stage cT1c PCa was found in 104/226 (46%) patients, in 70 (48.6%) and 34 (41.5%) of the men who underwent initial and repeat biopsy, respectively. An AZ PCa was found in 11.5 vs. 8.8% (p = 0.32) of the patients submitted to initial versus repeat biopsy, respectively. AZ cancers demonstrated a number of positive cores (p = 0.03), greatest percentage of cancer (p = 0.001) and total percentage of cancer (p = 0.001) significantly lower in comparison with PZ PCa; moreover, 56.2 vs. 36.5% of AZ versus PZ PCa were characterized by a microfocus of cancer (p = 0.001), respectively. Conclusions: AZ biopsies increase the detection rate of PCa (about 10% of cases) at initial and repeat biopsy, allowing reduction of the biopsy false-negative rate.

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