Prostate Cancer with Supraclavicular Lymphadenopathy and Bulky Abdominal Tumor

Kosugi, Shigeki; Mizumachi, Syoko; Kitajima, Akiko; Igarashi, Takayoshi; Hamada, Takamasa; Kaya, Hitoshi; Kurihara, Kazunao; Ogasawara, Koji; Sakata, Hitomi; Yamamoto, Masahiro; Nagamine, Masaru; Yamazaki, Hiroyuki

doi:10.2169/internalmedicine.46.0014

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…Lymphadenopathy is generally associated with prostate cancer metastasis and as predictable lymph nodes isolated were bigger in size due to inflammation in AIRE +/+ mice as compared to lymph nodes from AIRE −/− mice (Fig. 7g, h ) 35 , 36 . Tumor weight and volume have been measured (Fig.…”

Section: Resultsmentioning

confidence: 97%

AIRE promotes androgen-independent prostate cancer by directly regulating IL-6 and modulating tumor microenvironment

et al. 2018

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Early stage prostate cancers are dependent on androgens for their growth and survival and androgen withdrawal causes them to regress. Progressive prostate cancers eventually acquire androgen independence rendering anti-androgen therapy ineffective. However, the factors leading to this have not been adequately addressed. This study shows that AIRE finds differential expression in androgen-dependent and -independent prostate cancer cells. AIRE expression is more in androgen-independent cells due to its regulation by transcription factor Elk-1. These enhanced levels of AIRE modulate the prostate tumor microenvironment by transcriptionally activating a malignancy gene IL-6 in androgen-independent cells. Additionally, AIRE prevents the cancer cells from anticancer drug-induced death and enhances their invasiveness. Moreover, AIRE by modulating the cytokine milieu skews the tumor-associated macrophage polarization towards M2 phenotype with increased CD206 and CD163 expression. Subcutaneous mouse model of prostate cancer revealed AIRE+/+ mice forming a palpable tumor and presents lymphadenopathy however, only a small benign tumor is observed in AIRE−/− mice and lymph nodes appear normal in size. In conclusion, our findings suggest AIRE as a probable factor in promoting prostate cancer progression.

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Section: Resultsmentioning

confidence: 97%

AIRE promotes androgen-independent prostate cancer by directly regulating IL-6 and modulating tumor microenvironment

et al. 2018

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“…However, our patient's PET CT scans showed widespread involvement of the lymph nodes by the tumoral cells. First of all, we thought lymphoma was suitable for our patient because superficial and widespread lymphadenopathy is a symptom of systemic disease such as infection, collagen disease, and lymphoproliferative disorders, including acute and chronic lymphocytic leukemia and malignant lymphoma [8]. But our patient did not have any infectious symptoms or B symptoms (fever, perspiration, and weight loss) for malignant lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Generalized Lymphadenopathy: Unusual Presentation of Prostate Adenocarcinoma

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et al. 2011

Case Reports in Urology

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Generalized lymphadenopathy is a rare manifestation of metastatic prostate cancer. Here, we report the case of a 59-year-old male patient with supraclavicular, mediastinal, hilar, and retroperitoneal and inguinal lymphadenopathy, which suggested the diagnosis of lymphoma. There were no urinary symptoms. A biopsy of the inguinal lymph node was compatible with adenocarcinoma, whose prostatic origin was shown by immunohistochemical staining with PSA. The origin of the primary tumor was confirmed by directed prostate biopsy. We emphasize that a suspicion of prostate cancer in men with adenocarcinoma of undetermined origin is important for an adequate diagnostic and therapeutic approach.

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