Prostate cancer staging with extracapsular extension risk scoring using multiparametric MRI: a correlation with histopathology

Boesen, Lars; Chabanova, Elizaveta; Løgager, Vibeke; Balslev, I.; Mikines, K. J.; Thomsen, Henrik S.

doi:10.1007/s00330-014-3543-9

Cited by 72 publications

(59 citation statements)

References 35 publications

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“…7 Using ROC curve analyses, the accuracy of the ESUR ECE-score (AUC=0.82, Figure 1) for harboring extraprostatic disease was comparable to recent publications, thus demonstrating that standardized reading of mpMRI has the potential to predict EPE accurately. 23 Our results of the ECE-score were comparable to Boesen et al and…”

Section: Discussionsupporting

confidence: 94%

The Impact of Magnetic Resonance Imaging on Prediction of Extraprostatic Extension and Prostatectomy Outcome in Patients with Low-, Intermediate- and High-Risk Prostate Cancer: Try to Find a Standard

Radtke

Hadaschik

Wolf

et al. 2015

Journal of Endourology

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Section: Discussionsupporting

confidence: 94%

The Impact of Magnetic Resonance Imaging on Prediction of Extraprostatic Extension and Prostatectomy Outcome in Patients with Low-, Intermediate- and High-Risk Prostate Cancer: Try to Find a Standard

Radtke

Hadaschik

Wolf

et al. 2015

Journal of Endourology

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“…While some authors suggest few patients with cT3 disease are candidates for NVB preservation, 7 the incorporation of multi-parametric magnetic resonance imaging (MRI) to preoperative staging has challenged this paradigm, as recent studies have confirmed that MRI can identify extraprostatic extension (EPE) to a better extent than trans-rectal ultrasound and/or digital rectal examination. 8,9 …”

Section: Introductionmentioning

confidence: 99%

Erectile Function Recovery after Radical Prostatectomy in Men with High Risk Features

et al. 2016

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Purpose To describe the efficacy of radical prostatectomy to achieve complete primary tumor excision while preserving erectile function in a cohort of patients with high risk features, in whom surgical resection was tailored according to clinical staging, biopsy data, preoperative imaging, and intraoperative findings. Materials and Methods In a retrospective review, we identified 584 patients with high-risk features (Prostate-specific antigen ≥ 20ng/mL; clinical stage ≥ T3; preoperative Gleason grade 8–10) who underwent radical prostatectomy between 2006 and 2012. The probability of neurovascular bundle preservation was estimated based on preoperative characteristics. Positive surgical margin rates and erectile function recovery were determined in patients who had some degree of neurovascular bundle preservation. Results The neurovascular bundles were resected bilaterally in 69/584 (12%), and unilaterally in 91/584 (16%) patients. The rest had some degree of bilateral neurovascular bundle preservation. Preoperative features associated with a lower probability of neurovascular bundle preservation were: biopsy primary Gleason grade 5, and clinical stage T3. Among patients who underwent some degree of neurovascular bundle preservation, 125/515(24%) had a positive surgical margin and 75/160(47%) men with preoperatively functional erections and available erectile function follow-up had recovered erectile function within 2 years. Conclusions High-risk features should not be considered an indication for complete bilateral neurovascular bundle resection. Some degree of neurovascular bundle preservation can be safely performed by high volume surgeons in the majority of these patients with an acceptable rate of positive surgical margins. Nearly half of high-risk patients with functional erections preoperatively recover erectile function after radical prostatectomy.

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“…Traditionally, the presence of ECE was based on clinical parameters such as PSA, biopsy Gleason, and the extent of cancer involvement at biopsy [4,5].…”

Section: Discussionmentioning

confidence: 99%

“…Although specific prediction nomograms have been built and validated for this aim [4][5][6], none of them included apparent diffusion coefficient (ADC) from diffusionweighted imaging (DWI) to predict ECE.…”

Section: Introductionmentioning

confidence: 99%

Apparent diffusion coefficient in the evaluation of side-specific extracapsular extension in prostate cancer: Development and external validation of a nomogram of clinical use

Giganti

Coppola

Ambrosi

et al. 2016

Urologic Oncology: Seminars and Original Investigations

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Prostate cancer staging with extracapsular extension risk scoring using multiparametric MRI: a correlation with histopathology

Cited by 72 publications

References 35 publications

The Impact of Magnetic Resonance Imaging on Prediction of Extraprostatic Extension and Prostatectomy Outcome in Patients with Low-, Intermediate- and High-Risk Prostate Cancer: Try to Find a Standard

The Impact of Magnetic Resonance Imaging on Prediction of Extraprostatic Extension and Prostatectomy Outcome in Patients with Low-, Intermediate- and High-Risk Prostate Cancer: Try to Find a Standard

Erectile Function Recovery after Radical Prostatectomy in Men with High Risk Features

Apparent diffusion coefficient in the evaluation of side-specific extracapsular extension in prostate cancer: Development and external validation of a nomogram of clinical use

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